Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T78932
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| Former ID |
TTDNC00412
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| Target Name |
TYK2
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| Gene Name |
TYK2
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| Synonyms |
Nonreceptor tyrosineprotein kinase TYK2; TYK2
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| Target Type |
Research
|
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| Function |
Probably involved in intracellular signal transduction bybeing involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.
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| BioChemical Class |
Kinase
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| UniProt ID | |||||
| EC Number |
EC 2.7.10.2
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| Sequence |
MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHI
AHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREP AVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFK NESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRR FLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAP TDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHK AVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLV DGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHP YRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRA GDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTR TNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETAS LMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLAS ALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLA PECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQ LATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKI RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHII KYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYI HRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYY ASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKC PCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC |
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| Pathways | |||||
| KEGG Pathway | Osteoclast differentiation | ||||
| Jak-STAT signaling pathway | |||||
| Toxoplasmosis | |||||
| Hepatitis C | |||||
| Measles | |||||
| Influenza A | |||||
| Herpes simplex infection | |||||
| Epstein-Barr virus infection | |||||
| Pathway Interaction Database | IL27-mediated signaling events | ||||
| Signaling events mediated by PTP1B | |||||
| IL12-mediated signaling events | |||||
| IL6-mediated signaling events | |||||
| IL23-mediated signaling events | |||||
| Reactome | Interleukin-6 signaling | ||||
| MAPK3 (ERK1) activation | |||||
| MAPK1 (ERK2) activation | |||||
| Interferon alpha/beta signaling | |||||
| Regulation of IFNA signaling | |||||
| WikiPathways | Interferon type I signaling pathways | ||||
| IL-4 Signaling Pathway | |||||
| IL-6 signaling pathway | |||||
| Oncostatin M Signaling Pathway | |||||
| Interleukin-11 Signaling Pathway | |||||
| Type III interferon signaling | |||||
| Interferon alpha/beta signaling | |||||
| References | |||||
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