Target Information

Target General Infomation
Target ID
T83793
Former ID
TTDR00778
Target Name
Negative factor
Gene Name
nef
Synonyms
27 kDa protein; 3'ORF; F-protein; Nef protein; nef
Target Type
Clinical Trial
Disease Human immunodeficiency virus infection [ICD9: 279.3; ICD10: B20-B26]
Function
Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.
BioChemical Class
Lentivirus primate group Nef
UniProt ID
P03407
Sequence
MGGKWSKRSMGGWSAIRERMRRAEPRAEPAADGVGAVSRDLEKHGAITSSNTAATNADCA
WLEAQEEEEVGFPVRPQVPLRPMTYKAALDISHFLKEKGGLEGLIWSQRRQEILDLWIYH
TQGYFPDWQNYTPGPGIRYPLTFGWCFKLVPVEPEKVEEANEGENNSLLHPMSLHGMEDA
EKEVLVWRFDSKLAFHHMARELHPEYYKDC
Drugs and Mode of Action
Drug(s) F4co vaccine Drug Info Phase 2 Human immunodeficiency virus infection [523204], [548656]
LIPO-5 Drug Info Phase 2 Human immunodeficiency virus infection [523727]
Ad35-GRIN Drug Info Phase 1/2 Human immunodeficiency virus infection [524697]
Ad35-GRIN/ENV Drug Info Phase 1 Human immunodeficiency virus infection [523741]
GSK-732461 Drug Info Discontinued in Phase 2 Human immunodeficiency virus infection [548656]
Inhibitor MYRISTIC ACID Drug Info [551374]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
DRM DRM Info
References
Ref 523204ClinicalTrials.gov (NCT01218113) Efficacy and Safety of GSK Biologicals HIV Vaccine in Antiretroviral Therapy (ART)-naive HIV-1 Infected Persons. U.S. National Institutes of Health.
Ref 523727ClinicalTrials.gov (NCT01492985) Lipopeptide Immunisation With GTU-multiHIV Trial. U.S. National Institutes of Health.
Ref 523741ClinicalTrials.gov (NCT01496989) Safety and Immunogenicity Study of HIV-MAG Vaccine +/- IL-12 and Ad35-GRIN/ENV in HIV-uninfected Volunteers. U.S. National Institutes of Health.
Ref 524697ClinicalTrials.gov (NCT02099994) Safety & Immunogenicity of HIV Vaccines in Healthy Kenyan Adults. U.S. National Institutes of Health.
Ref 548656Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027409)
Ref 531994A phase I double blind, placebo-controlled, randomized study of a multigenic HIV-1 adenovirus subtype 35 vector vaccine in healthy uninfected adults. PLoS One. 2012;7(8):e41936.
Ref 533201HIV specific responses induced in nonhuman primates with ANRS HIV-Lipo-5 vaccine combined with rMVA-HIV prime or boost immunizations. Vaccine. 2015 May 11;33(20):2354-9.
Ref 549839Preventive technologies, research toward a cure, and immune-based and gene therapies. HIV Treatment Bulletin. 30 June 2013.
Ref 550167EP patent application no. 2621528, Vaccine.
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.

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