Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | (S)-2-(3-{[Bis-(4-nitro-benzyl)-amino]-methyl}-benzoylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3H-imidazol-4-yl)-methoxymethyl]-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| Ftase --- FPTase | 6-{3-[3-(4-Cyano-benzyl)-3H-imidazol-4-yl]-3-hydroxy-prop-1-ynyl}-3''-ethoxy-biphenyl-3-carbonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-2-carbonyl]-amino}-4-methyl-pentanoic acid methyl ester | Drug Info |
| Ftase --- FPTase | 2-(2-{(S)-1-[(S)-1-((S)-1-Carboxy-2-hydroxy-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-2-methyl-propylcarbamoyl}-ethyl)-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid | Drug Info |
| Ftase --- FPTase | 1-[(2R,3R)-3-(2-Chloro-thiophen-3-ylmethoxy)-2,3-dihydro-naphtho[1,2-b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| Ftase --- FPTase | (S)-2-[(2'-Methyl-5-pyridin-3-ylethynyl-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | (S)-2-Amino-1-[4-(8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-3-(4-methoxy-benzylsulfanyl)-propan-1-one | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid 3-trifluoromethoxy-benzyl ester | Drug Info |
| Ftase --- FPTase | N-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-N-(5-cyano-3''-ethoxy-biphenyl-2-ylmethyl)-methanesulfonamide | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-methyl-piperidin-4-yl)-ethanone | Drug Info |
| Ftase --- FPTase | (S)-2-[2-({(S)-3-Methyl-2-[2-(4-nitro-benzylsulfanyl)-acetylamino]-pentyl}-naphthalen-1-ylmethyl-amino)-acetylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 1-{2-[3-(4-Chloro-benzyl)-3H-imidazol-4-yl]-acetyl}-5-naphthalen-1-yl-1,2,3,6-tetrahydro-pyridine-4-carbonitrile | Drug Info |
| Ftase --- FPTase | 4-{2-[(S)-4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-2-(2-methoxy-ethyl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid amide | Drug Info |
| Ftase --- FPTase | [4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-(1-methyl-piperidin-3-yl)-methanone | Drug Info |
| Ftase --- FPTase | 4-[3-(5,3'-Dichloro-biphenyl-2-yl)-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-benzonitrile | Drug Info |
| Ftase --- FPTase | (S)-3,10-Dibromo-8-chloro-11-(1-methanesulfonyl-piperidin-4-yl)-11H-benzo[5,6]cyclohepta[1,2-b]pyridine | Drug Info |
| Ftase --- FPTase | (S)-2-({5-[(E)-2-(3H-Imidazol-4-yl)-vinyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 4-{5-[(S)-4-(3-Chloro-phenyl)-2-ethanesulfonylmethyl-5-oxo-piperazin-1-ylmethyl]-imidazol-1-ylmethyl}-benzonitrile | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-10-methyl-10,11-dihydro-5H-4,10-diaza-dibenzo[a,d]cyclohepten-5-yl)-piperazin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| Ftase --- FPTase | 4-((5-((benzyl(1-benzyl-2-oxopyrrolidin-3-yl)amino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| Ftase --- FPTase | 2-Amino-3-[3'-(5H-tetrazol-5-yl)-biphenyl-4-ylamino]-propane-1-thiol 8 (FTI-2102) | Drug Info |
| Ftase --- FPTase | 1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| Ftase --- FPTase | 3-(3-(1H-imidazol-1-yl)propyl)-1-(4-bromobenzyl)-5-methyl-5-(naphthalen-1-yl)imidazolidine-2,4-dione | Drug Info |
| Ftase --- FPTase | N-((4-(4-cyanobenzyl)-4H-1,2,4-triazol-3-yl)methyl)-N-(4-fluorobenzyl)quinoline-2-carboxamide | Drug Info |
| Ftase --- FPTase | 4-(5-{[1-(2-Methoxy-pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| Ftase --- FPTase | 1-[4-(3-Amino-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| Ftase --- FPTase | (S)-2-((R)-2-((S)-2-((R)-2-amino-3-mercaptopropanamido)-3-methylbutanamido)-3-(4-hydroxy-2,5-dimethylphenyl)propanamido)-4-(methylthio)butanoic acid | Drug Info |
| Ftase --- FPTase | 4-{2-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid tert-butylamide | Drug Info |
| Ftase --- FPTase | N-(2-Cyano-ethyl)-N-cyclopropyl-2-(2-o-tolyl-1H-indol-3-yl)-acetamide | Drug Info |
| Ftase --- FPTase | 2-(1-Acetyl-piperidin-4-yl)-1-[4-((S)-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-ethanone | Drug Info |
| Ftase --- FPTase | (4E,8E)-2-((S)-4-{1-[1-((S)-1-(S)-Carboxy-2-hydroxy-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-2-methyl-propylcarbamoyl}-butyl)-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid | Drug Info |
| Ftase --- FPTase | Cyanoguanidine derivative | Drug Info |
| Ftase --- FPTase | (20R)-15-bromo-19,20,21,22-tetrahydro-19-oxo-17H-18,20-etheno-6,10:12,16-dimetheno-16H-imidazo[3,4-h][1,8,11,14]oxatriazacycloeicosine-9-carbonitrile | Drug Info |
| Ftase --- FPTase | 4-((3-(3-(1H-imidazol-1-yl)propyl)-5-methyl-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)methyl)benzoic acid | Drug Info |
| Ftase --- FPTase | Pyridine-2-sulfonic acid benzyl-[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-amide | Drug Info |
| Ftase --- FPTase | (S)-2-[(E)-(R)-5-((R)-2-Amino-3-mercapto-propionylamino)-2-benzyl-pent-3-enoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | Lithium; (S)-2-({5-[5-(3-methoxy-phenyl)-furan-2-ylmethoxymethyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyrate | Drug Info |
| Ftase --- FPTase | 2-[1-(4-Bromo-benzyl)-1H-indol-3-yl]-N-isopropyl-N-pyridin-4-ylmethyl-acetamide | Drug Info |
| Ftase --- FPTase | 3-(3-(1H-imidazol-1-yl)propyl)-1-(4-(methylthio)benzyl)-5-methyl-5-(naphthalen-1-yl)imidazolidine-2,4-dione | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Cyano-benzyl)-2-methyl-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid 2-methoxymethyl-benzyl ester | Drug Info |
| Ftase --- FPTase | N-(2,4-difluorobenzyl)-N-((4-((5-cyanopyridin-2-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)quinoline-2-carboxamide | Drug Info |
| Ftase --- FPTase | 1-[(2R,3R)-3-(2,6-Dichloro-benzyloxy)-5-fluoro-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| Ftase --- FPTase | N-Cyclobutyl-2-(2-phenyl-1H-indol-3-yl)-N-pyridin-4-ylmethyl-acetamide | Drug Info |
| Ftase --- FPTase | (S)-4-Methylsulfanyl-2-[2-({(S)-3-methyl-2-[2-(4-trifluoromethyl-benzylsulfanyl)-acetylamino]-pentyl}-naphthalen-1-ylmethyl-amino)-acetylamino]-butyric acid | Drug Info |
| Ftase --- FPTase | (S)-2-[(3aR,6R,9S)-3-(1,5-Dimethyl-hexyl)-9-ethyl-3a,6-dimethyl-7-oxo-dodecahydro-cyclopenta[a]naphthalen-6-ylmethyl]-succinic acid | Drug Info |
| Ftase --- FPTase | 6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-(2,3-dichloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| Ftase --- FPTase | 2-[(2-{[2-(2-{2-[3-(1-Carboxy-3-methylsulfanyl-propylcarbamoyl)-3,4-dihydro-1H-isoquinolin-2-yl]-acetylamino}-ethyldisulfanyl)-ethylcarbamoyl]-methyl}-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 8-Chloro-11-(1-methanesulfonyl-piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine | Drug Info |
| Ftase --- FPTase | N-[6-Cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-N-(2-methyl-allyl)-methanesulfonamide | Drug Info |
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