Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | 1-{4-[4-((R)-8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carbonyl]-piperidin-1-yl}-ethanone | Drug Info |
| Ftase --- FPTase | 6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imidazol-4-yl)-prop-1-ynyl]-3'-trifluoromethoxy-biphenyl-3-carbonitrile | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| Ftase --- FPTase | 3-Benzo[1,3]dioxol-5-yl-4-[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethoxymethyl]-benzonitrile | Drug Info |
| Ftase --- FPTase | 4-{2-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid phenyl ester | Drug Info |
| Ftase --- FPTase | (S)-2-[2-({(S)-3-Methyl-2-[2-(4-methyl-benzylsulfanyl)-acetylamino]-pentyl}-naphthalen-1-ylmethyl-amino)-acetylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 6-[(3-Chloro-4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-(3-chloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| Ftase --- FPTase | 2-(2,4-Dichloro-phenylsulfanyl)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-{[5-((R)-2-Amino-3-mercapto-propionylamino)-naphthalene-1-carbonyl]-amino}-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] 1-propylamide 2-[(pyridin-3-ylmethyl)-amide] | Drug Info |
| Ftase --- FPTase | 6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-(2,5-dichloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-1-oxy-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| Ftase --- FPTase | 6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-[1,1';4',1'']terphenyl-3-carbonitrile | Drug Info |
| Ftase --- FPTase | N-Ethyl-2-(2-phenyl-1H-indol-3-yl)-N-pyridin-4-ylmethyl-acetamide | Drug Info |
| Ftase --- FPTase | 1-[4-(3-Ethyl-10-methoxy-8-methyl-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| Ftase --- FPTase | 1-[4-((S)-3-Bromo-7,8-dichloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| Ftase --- FPTase | 4-(5-{[2-(3-Chloro-benzyl)-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| Ftase --- FPTase | 4-((5-((4-(3-chlorophenyl)-3-oxopiperazin-1-yl)methyl)-1H-imidazol-1-yl)methyl)-2-(naphthalen-2-yloxy)benzonitrile | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-(4-fluoro-phenyl)-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| Ftase --- FPTase | 4-(1-ethynyl)-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | Drug Info |
| Ftase --- FPTase | (S)-2-(2-{[(S)-2-(2-Benzylsulfanyl-acetylamino)-3-methyl-pentyl]-naphthalen-1-ylmethyl-amino}-acetylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 17-oxo-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid (1-methyl-piperidin-3-yl)-amide | Drug Info |
| Ftase --- FPTase | 6-[(3-Bromo-4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-(3,5-dichloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-(2-((S)-2-amino-3-mercaptopropylamino)-1-naphthamido)-4-(methylthio)butanoic acid | Drug Info |
| Ftase --- FPTase | (S)-2-[2-({(S)-3-Methyl-2-[2-(pyridin-4-ylmethylsulfanyl)-acetylamino]-pentyl}-naphthalen-1-ylmethyl-amino)-acetylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | (R)-2-({3-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methyl-butyrylamino]-naphthalene-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-cycloheptanecarbonyl-piperazine-2-carboxylic acid (pyridin-3-ylmethyl)-amide | Drug Info |
| Ftase --- FPTase | N-{2-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-oxo-ethyl}-2-phenyl-acetamide | Drug Info |
| Ftase --- FPTase | Sodium salt of Phosphoric acid mono-[(3,7,11-trimethyl-dodeca-2,6,10-trienyloxycarbamoyl)-methyl] ester | Drug Info |
| Ftase --- FPTase | 4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3-(4-nitro-phenylethynyl)-benzonitrile | Drug Info |
| Ftase --- FPTase | (R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methylsulfanyl-butyric acid methyl ester | Drug Info |
| Ftase --- FPTase | N-Cyclopropyl-2-(2-phenyl-1H-indol-3-yl)-N-pyridin-4-ylmethyl-acetamide | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Chloro-phenyl)-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-2-naphthalen-1-yl-benzonitrile | Drug Info |
| Ftase --- FPTase | 4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-oxo-ethyl}-piperidine-1-sulfonic acid amide | Drug Info |
| Ftase --- FPTase | 2-(2,4-Dichloro-benzenesulfonyl)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-{2-[3-((R)-2-Amino-3-mercapto-propylamino)-phenyl]-acetylamino}-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | (S)-2-[(2S,5R)-5-((R)-2-Amino-3-mercapto-propylamino)-2-benzyl-6-methyl-heptanoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | (S)-2-({(2S,3S,6S)-6-[((R)-2-Amino-3-tert-butyldisulfanyl-propionylamino)-methyl]-3-benzyloxy-tetrahydro-pyran-2-carbonyl}-amino)-4-methanesulfinyl-butyric acid | Drug Info |
| Ftase --- FPTase | 4-((5-((4-(3-chlorophenyl)-3-oxopiperazin-1-yl)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-[(5-{2-[4-(Adamantane-1-carbonyl)-pyridin-3-yl]-vinyl}-2'-methyl-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | N-Cyclobutyl-2-(2-phenyl-1H-indol-3-yl)-N-pyridin-3-ylmethyl-acetamide | Drug Info |
| Ftase --- FPTase | 15-benzyl-17-oxo-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide | Drug Info |
| Ftase --- FPTase | (S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propionylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-hexanoic acid | Drug Info |
| Ftase --- FPTase | (S)-2-Amino-1-(4-{2-[4-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidin-1-yl)-3-hydroxy-propan-1-one | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid benzo[1,3]dioxol-5-ylmethyl ester | Drug Info |
| Ftase --- FPTase | Lithium; (S)-2-({5-[5-(4-methoxy-phenyl)-furan-2-ylmethoxymethyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyrate | Drug Info |
| Ftase --- FPTase | (S)-2-Amino-1-(4-{2-[4-((R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-oxo-ethyl}-piperidin-1-yl)-propan-1-one | Drug Info |
| Ftase --- FPTase | SID405162 | Drug Info |
| Ftase --- FPTase | (1R,8R,9S,13S)-11-[2-(2-methoxyphenyl)prop-2-enoyl]-1-(4-methylphenyl)-11-azatetracyclo[6.5.2.0^{2,7}.0^{9,13}]pentadeca-2,4,6-triene-9-carboxylic acid | Drug Info |
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