Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T38996
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| Former ID |
TTDR00374
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| Target Name |
Phospholipase D1
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| Gene Name |
PLD1
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| Synonyms |
Choline phosphatase 1; HPLD1; PLD 1; Phosphatidylcholine-hydrolyzing phospholipase D1; PLD1
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| Target Type |
Research
|
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| Function |
Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity).
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| BioChemical Class |
Phosphoric diester hydrolases
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| Target Validation |
T38996
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| UniProt ID | |||||
| EC Number |
EC 3.1.4.4
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| Sequence |
MSLKNEPRVNTSALQKIAADMSNIIENLDTRELHFEGEEVDYDVSPSDPKIQEVYIPFSA
IYNTQGFKEPNIQTYLSGCPIKAQVLEVERFTSTTRVPSINLYTIELTHGEFKWQVKRKF KHFQEFHRELLKYKAFIRIPIPTRRHTFRRQNVREEPREMPSLPRSSENMIREEQFLGRR KQLEDYLTKILKMPMYRNYHATTEFLDISQLSFIHDLGPKGIEGMIMKRSGGHRIPGLNC CGQGRACYRWSKRWLIVKDSFLLYMKPDSGAIAFVLLVDKEFKIKVGKKETETKYGIRID NLSRTLILKCNSYRHARWWGGAIEEFIQKHGTNFLKDHRFGSYAAIQENALAKWYVNAKG YFEDVANAMEEANEEIFITDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLY KEVELALGINSEYTKRTLMRLHPNIKVMRHPDHVSSTVYLWAHHEKLVIIDQSVAFVGGI DLAYGRWDDNEHRLTDVGSVKRVTSGPSLGSLPPAAMESMESLRLKDKNEPVQNLPIQKS IDDVDSKLKGIGKPRKFSKFSLYKQLHRHHLHDADSISSIDSTSSYFNHYRSHHNLIHGL KPHFKLFHPSSESEQGLTRPHADTGSIRSLQTGVGELHGETRFWHGKDYCNFVFKDWVQL DKPFADFIDRYSTPRMPWHDIASAVHGKAARDVARHFIQRWNFTKIMKSKYRSLSYPFLL PKSQTTAHELRYQVPGSVHANVQLLRSAADWSAGIKYHEESIHAAYVHVIENSRHYIYIE NQFFISCADDKVVFNKIGDAIAQRILKAHRENQKYRVYVVIPLLPGFEGDISTGGGNALQ AIMHFNYRTMCRGENSILGQLKAELGNQWINYISFCGLRTHAELEGNLVTELIYVHSKLL IADDNTVIIGSANINDRSMLGKRDSEMAVIVQDTETVPSVMDGKEYQAGRFARGLRLQCF RVVLGYLDDPSEDIQDPVSDKFFKEVWVSTAARNATIYDKVFRCLPNDEVHNLIQLRDFI NKPVLAKEDPIRAEEELKKIRGFLVQFPFYFLSEESLLPSVGTKEAIVPMEVWT |
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| Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
| TEP | EXP Info | ||||
| Pathways | |||||
| BioCyc Pathway | Phospholipases | ||||
| KEGG Pathway | Glycerophospholipid metabolism | ||||
| Ether lipid metabolism | |||||
| Metabolic pathways | |||||
| Ras signaling pathway | |||||
| cAMP signaling pathway | |||||
| Sphingolipid signaling pathway | |||||
| Endocytosis | |||||
| Fc gamma R-mediated phagocytosis | |||||
| Glutamatergic synapse | |||||
| GnRH signaling pathway | |||||
| Pathways in cancer | |||||
| Pancreatic cancer | |||||
| Choline metabolism in cancer | |||||
| PANTHER Pathway | Angiogenesis | ||||
| Ras Pathway | |||||
| Pathway Interaction Database | RhoA signaling pathway | ||||
| Arf6 trafficking events | |||||
| CDC42 signaling events | |||||
| Arf6 downstream pathway | |||||
| mTOR signaling pathway | |||||
| ErbB1 downstream signaling | |||||
| IL8- and CXCR1-mediated signaling events | |||||
| Alpha-synuclein signaling | |||||
| Reactome | Role of phospholipids in phagocytosis | ||||
| WikiPathways | EGF/EGFR Signaling Pathway | ||||
| TSH signaling pathway | |||||
| References | |||||
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