| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T10897 | ||||
| Target Name | Acyl-CoA desaturase | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | CVT-12012 | Drug Info | IC50 = 38 nM | [530248] | |
| MF-152 | Drug Info | IC50 = 254 nM | [530690] | ||
| CVT-12012 | Drug Info | IC50 = 6.1 nM | [530248] | ||
| MF-152 | Drug Info | IC50 = 106 nM | [530690] | ||
| 2-(4-benzoylpiperazin-1-yl)thiazole-5-carboxamide | Drug Info | IC50 = 2000 nM | [530276] | ||
| MF-152 | Drug Info | IC50 = 2.3 nM | [530568] | ||
| References | |||||
| Ref 530248 | Bioorg Med Chem Lett. 2009 Aug 1;19(15):4070-4. Epub 2009 Jun 13.Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors. | ||||
| Ref 530690 | Bioorg Med Chem Lett. 2010 Mar 1;20(5):1593-7. Epub 2010 Jan 21.SAR and optimization of thiazole analogs as potent stearoyl-CoA desaturase inhibitors. | ||||
| Ref 530248 | Bioorg Med Chem Lett. 2009 Aug 1;19(15):4070-4. Epub 2009 Jun 13.Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors. | ||||
| Ref 530690 | Bioorg Med Chem Lett. 2010 Mar 1;20(5):1593-7. Epub 2010 Jan 21.SAR and optimization of thiazole analogs as potent stearoyl-CoA desaturase inhibitors. | ||||
| Ref 530276 | Bioorg Med Chem Lett. 2009 Sep 1;19(17):5214-7. Epub 2009 Jul 9.Thiazole analog as stearoyl-CoA desaturase 1 inhibitor. | ||||
| Ref 530568 | Bioorg Med Chem Lett. 2010 Jan 15;20(2):499-502. Epub 2009 Nov 26.Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438). | ||||
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