| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T27325 | ||||
| Target Name | DNA topoisomerase I | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | 4-hydroxysaprothoquinone | Drug Info | IC50 = 800 nM | [1] | |
| CHO793076 | Drug Info | IC50 = 2300 nM | [2] | ||
| (5Z,9Z)-5,9-heptacosadienoic acid | Drug Info | IC50 = 900 nM | [3] | ||
| TOPOSTATIN | Drug Info | IC50 = 17000 nM | [4] | ||
| Topotecan | Drug Info | IC50 = 300 nM | |||
| References | |||||
| REF 1 | J Nat Prod. 2002 Jul;65(7):1016-20.Bioactive abietane and seco-abietane diterpenoids from Salvia prionitis. | ||||
| REF 2 | Bioorg Med Chem Lett. 2009 Apr 1;19(7):2018-21. Epub 2009 Feb 12.Synthesis of new camptothecin analogs with improved antitumor activities. | ||||
| REF 3 | J Nat Prod. 2002 Nov;65(11):1715-8.Total synthesis and biological evaluation of (5Z,9Z)-5,9-hexadecadienoic acid, an inhibitor of human topoisomerase I. | ||||
| REF 4 | J Nat Prod. 2001 Feb;64(2):204-7.Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba. | ||||
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