| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T78111 | ||||
| Target Name | Nicotinic acetylcholine receptor | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | Dianicline | Drug Info | Ki = 42900 nM | [552798] | |
| Nicotine | Drug Info | Ki = 19.4 nM | [552407] | ||
| PROTOSTEMODIOL | Drug Info | IC50 = 10000 nM | [529235] | ||
| References | |||||
| Ref 552798 | Low molecular weight inhibitors of the protease anthrax lethal factor. Mini Rev Med Chem. 2008 Mar;8(3):290-306. | ||||
| Ref 552407 | Receptor binding thermodynamics at the neuronal nicotinic receptor. Curr Top Med Chem. 2004;4(3):361-8. | ||||
| Ref 529235 | J Nat Prod. 2008 Jan;71(1):112-6. Epub 2007 Dec 29.Alkaloids from stems and leaves of Stemona japonica and their insecticidal activities. | ||||
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