Target Validation Information
Target ID T60366
Target Name Ornithine decarboxylase
Target Type
Successful
Drug Potency against Target Eflornithine Drug Info Ki = 2200???000 nM [553082]
3-methoxy-4-hydroxylonchocarpin Drug Info IC50 = 3600 nM [525437]
4-hydroxylonchocarpin Drug Info IC50 = 4700 nM [525437]
ZAPOTIN Drug Info IC50 = 3400 nM [528622]
LONCHOCARPUSONE Drug Info IC50 = 2600 nM [525437]
3-(Aminooxy)propan-1-amine hydrochloride Drug Info IC50 = 35 nM [531018]
1-Amino-3-(aminoxy)-2-propanol Dihydrochloride Drug Info IC50 = 39 nM [531018]
References
Ref 553082A molecular mechanism for eflornithine resistance in African trypanosomes. PLoS Pathog. 2010 Nov 24;6(11):e1001204. doi: 10.1371/journal.ppat.1001204.
Ref 525437J Nat Prod. 1999 Feb;62(2):205-10.New bioactive flavonoids and stilbenes in cub?| resin insecticide.
Ref 525437J Nat Prod. 1999 Feb;62(2):205-10.New bioactive flavonoids and stilbenes in cub?| resin insecticide.
Ref 528622J Med Chem. 2007 Jan 25;50(2):350-5.Synthesis and cancer chemopreventive activity of zapotin, a natural product from Casimiroa edulis.
Ref 525437J Nat Prod. 1999 Feb;62(2):205-10.New bioactive flavonoids and stilbenes in cub?| resin insecticide.
Ref 531018Bioorg Med Chem Lett. 2010 Aug 1;20(15):4364-6. Epub 2010 Jun 17.Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif.
Ref 531018Bioorg Med Chem Lett. 2010 Aug 1;20(15):4364-6. Epub 2010 Jun 17.Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif.

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