| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T54132 | ||||
| Target Name | Potassium voltage-gated channel subfamily KQT member 3 | ||||
| Target Type | Successful |
||||
| Action against Disease Model | ICA-105665 | Anticonvulsant activity of ICA-105665 in rat models ED50 is 11.1 ( mg/kg) | [553076] | Drug Info | |
| The Effect of Target Knockout, Knockdown or Genetic Variations | In h uMans missense or deletion mutations in KV7.2 or KV7.3 cause benign familial neonatal convulsions (BFNC), an autosomal dominant epilepsy of infancy.Although the seizures inBFNC typically resolve by 3 months of age, BFNC is associated with an increased incidence of various forms of epilepsy later in life suggesting a strong link between KV7.2 and KV7.3 mutations and epilepsy. | [553076] | |||
| References | |||||
| Ref 553076 | Progress report on new antiepileptic drugs: a summary of the Tenth Eilat Conference (EILAT X). Epilepsy Res. 2010 Dec;92(2-3):89-124. doi: 10.1016/j.eplepsyres.2010.09.001. | ||||
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