| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T62184 | ||||
| Target Name | Sodium- and chloride-dependent GABA transporter 1 | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | 4-Hydroxy-piperidine-3-carboxylic acid | Drug Info | IC50 = 11000 nM | [1] | |
| (S)-Piperidine-3-carboxylic acid | Drug Info | IC50 = 2660 nM | [2] | ||
| 2,4-Diamino-butyric acid(GABA) | Drug Info | IC50 = 2000 nM | [3] | ||
| (R)-Piperidine-3-carboxylic acid | Drug Info | IC50 = 2600 nM | [2] | ||
| GAMMA-AMINO-BUTANOIC ACID | Drug Info | IC50 = 2640 nM | [2] | ||
| References | |||||
| REF 1 | J Med Chem. 1982 Oct;25(10):1157-62.Hydroxy- and amino-substituted piperidinecarboxylic acids as gamma-aminobutyric acid agonists and uptake inhibitors. | ||||
| REF 2 | J Med Chem. 2004 Nov 4;47(23):5620-9.Novel secoergoline derivatives inhibit both GABA and glutamate uptake in rat brain homogenates: synthesis, in vitro pharmacology, and modeling. | ||||
| REF 3 | J Med Chem. 1986 Feb;29(2):224-9.Glycine antagonists. Synthesis, structure, and biological effects of some bicyclic 5-isoxazolol zwitterions. | ||||
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