| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T30081 | ||||
| Target Name | Thymidine kinase | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | 1-[2-(2-triphenylmethoxyethoxy)ethyl]thymine | Drug Info | IC50 = 9700 nM | [1] | |
| 1-[6-(triphenylmethoxy)hexyl]thymine | Drug Info | IC50 = 500 nM | [1] | ||
| L-5-iodo-2'-deoxyuridine | Drug Info | IC50 = 2000 nM | [2] | ||
| 5-propyl-2'-deoxyuridine | Drug Info | IC50 = 4200 nM | [2] | ||
| 3'-(1,2,3-Triazol-1-yl)-3'-deoxy-beta-D-thymidine | Drug Info | IC50 = 4700 nM | [3] | ||
| N2-(3-trifluoromethylphenyl)guanine | Drug Info | IC50 = 3500 nM | [2] | ||
| 1-[5-(triphenylmethoxy)pentyl]thymine | Drug Info | IC50 = 2500 nM | [1] | ||
| 1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine | Drug Info | Ki = 500 nM | [1] | ||
| 2-phenylamino-9-(4-hydroxy-butyl)-6-oxopurine | Drug Info | IC50 = 11500 nM | [2] | ||
| Edoxudine | Drug Info | IC50 = 150 nM | [2] | ||
| L-5-(bromovinyl)deoxyuridine | Drug Info | IC50 = 15000 nM | [2] | ||
| 1-[7-(triphenylmethoxy)heptyl]thymine | Drug Info | IC50 = 4700 nM | [1] | ||
| References | |||||
| REF 1 | J Med Chem. 2006 Dec 28;49(26):7766-73.N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors. | ||||
| REF 2 | Antimicrob Agents Chemother. 2007 Jun;51(6):2028-34. Epub 2007 Apr 16.Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides. | ||||
| REF 3 | J Med Chem. 2010 Apr 8;53(7):2902-12.3'-[4-Aryl-(1,2,3-triazol-1-yl)]-3'-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase. | ||||
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