| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T25889 | ||||
| Target Name | Adenylate cyclase | ||||
| Target Type | Discontinued |
||||
| Drug Potency against Target | NSC-270718 | Drug Info | IC50 = 11000 nM | [529597] | |
| 2-hydroxy-17beta-estradiol | Drug Info | IC50 = 3000 nM | [529597] | ||
| NSC-88915 | Drug Info | IC50 = 1100 nM | [529597] | ||
| 2,5-didesoxy-3-ATP | Drug Info | IC50 = 700 nM | [529597] | ||
| N6-CYCLOPENTYLADENOSINE | Drug Info | IC50 = 3200 nM | [528965] | ||
| DEOXYADENOSINE | Drug Info | IC50 = 15000 nM | [526967] | ||
| References | |||||
| Ref 529597 | J Med Chem. 2008 Aug 14;51(15):4456-64. Epub 2008 Jul 17.Structure-based development of novel adenylyl cyclase inhibitors. | ||||
| Ref 529597 | J Med Chem. 2008 Aug 14;51(15):4456-64. Epub 2008 Jul 17.Structure-based development of novel adenylyl cyclase inhibitors. | ||||
| Ref 529597 | J Med Chem. 2008 Aug 14;51(15):4456-64. Epub 2008 Jul 17.Structure-based development of novel adenylyl cyclase inhibitors. | ||||
| Ref 529597 | J Med Chem. 2008 Aug 14;51(15):4456-64. Epub 2008 Jul 17.Structure-based development of novel adenylyl cyclase inhibitors. | ||||
| Ref 528965 | J Med Chem. 1991 Dec;34(12):3388-90.Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors. | ||||
| Ref 526967 | J Med Chem. 2004 Feb 26;47(5):1207-13.Synthesis of 2',5'-dideoxy-2-fluoroadenosine and 2',5'-dideoxy-2,5'-difluoroadenosine: potent P-site inhibitors of adenylyl cyclase. | ||||
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