| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T78892 | ||||
| Target Name | mRNA of integrin alpha-4 | ||||
| Target Type | Clinical Trial |
||||
| Drug Potency against Target | MK-0668 | Drug Info | IC50 = 0.15 nM | [530343] | |
| TR-14035 | Drug Info | IC50 = 61 nM | [527324] | ||
| References | |||||
| Ref 530343 | Bioorg Med Chem Lett. 2009 Oct 1;19(19):5803-6. Epub 2009 Jul 28.Discovery of N-{N-[(3-cyanobenzene) sulfonyl]-4(R)-(3,3-difluoropiperidin-1-yl)-(l)-prolyl}-4-[(3',5'-dichloro-isonicotinoyl) amino]-(l)-phenylalanine (MK-0617), a highly potent and orally active VLA-4 antagonist. | ||||
| Ref 527324 | Bioorg Med Chem Lett. 2005 Jan 3;15(1):217-20.2,3-Diphenylpropionic acids as potent VLA-4 antagonists. | ||||
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