Target Validation Information | |||||
---|---|---|---|---|---|
Target ID | T35527 | ||||
Target Name | Arachidonate 12-lipoxygenase, 12S-type | ||||
Target Type | Discontinued |
||||
Drug Potency against Target | Polybrominated diphenyl ether derivative | Drug Info | IC50 = 2300 nM | [527145] | |
DYSIDENIN | Drug Info | Ki = 9000 nM | [529029] | ||
NEODYSIDENIN | Drug Info | Ki = 17000 nM | [529029] | ||
(-)-7-N-methyldibromophakellin | Drug Info | IC50 = 10700 nM | [527187] | ||
PUUPEHENONE | Drug Info | IC50 = 2400 nM | [526556] | ||
Dimethylnordihydroguarierate acid | Drug Info | IC50 = 3100 nM | [526556] | ||
(+)-(5S,8S,10S)-20-methoxypuupehenol | Drug Info | IC50 = 280 nM | [526556] | ||
CHLOROPUUPEHENONE | Drug Info | IC50 = 2400 nM | [526556] | ||
Jaspic acid | Drug Info | IC50 = 7600 nM | [526556] | ||
2,3,4,5-Tetrabromo-6-(2,4-dibromo-phenoxy)-phenol | Drug Info | IC50 = 700 nM | [527145] | ||
(+)-(5S,8S,10S)-20-methoxy-9,15-ene-puupehenol | Drug Info | IC50 = 780 nM | [526556] | ||
(+)-(5S,8S,9R,10S)-20-methoxypuupehenone | Drug Info | IC50 = 260 nM | [526556] | ||
3,4,6-Tribromo-2-(2,4-dibromo-phenoxy)-phenol | Drug Info | IC50 = 6000 nM | [527145] | ||
Isojaspic acid | Drug Info | IC50 = 3100 nM | [530468] | ||
PUUPEHEDIONE | Drug Info | IC50 = 18000 nM | [530468] | ||
References | |||||
Ref 527145 | J Med Chem. 2004 Jul 29;47(16):4060-5.Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. | ||||
Ref 529029 | Bioorg Med Chem. 2007 Nov 15;15(22):6900-8. Epub 2007 Aug 22.Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. | ||||
Ref 529029 | Bioorg Med Chem. 2007 Nov 15;15(22):6900-8. Epub 2007 Aug 22.Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. | ||||
Ref 527187 | J Nat Prod. 2004 Aug;67(8):1256-61.An analysis of phakellin and oroidin structures stimulated by further study of an Agelas sponge. | ||||
Ref 526556 | J Nat Prod. 2003 Feb;66(2):230-5.Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. | ||||
Ref 526556 | J Nat Prod. 2003 Feb;66(2):230-5.Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. | ||||
Ref 526556 | J Nat Prod. 2003 Feb;66(2):230-5.Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. | ||||
Ref 526556 | J Nat Prod. 2003 Feb;66(2):230-5.Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. | ||||
Ref 526556 | J Nat Prod. 2003 Feb;66(2):230-5.Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. | ||||
Ref 527145 | J Med Chem. 2004 Jul 29;47(16):4060-5.Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. | ||||
Ref 526556 | J Nat Prod. 2003 Feb;66(2):230-5.Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. | ||||
Ref 526556 | J Nat Prod. 2003 Feb;66(2):230-5.Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. | ||||
Ref 527145 | J Med Chem. 2004 Jul 29;47(16):4060-5.Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. | ||||
Ref 530468 | J Nat Prod. 2009 Oct;72(10):1857-63.Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. | ||||
Ref 530468 | J Nat Prod. 2009 Oct;72(10):1857-63.Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. |
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