Target Validation Information
Target ID T17140
Target Name P2X purinoceptor 3
Target Type
Clinical Trial
Drug Potency against Target Cyclic LVVYPWT Drug Info IC50 = 82.4 nM [528976]
ISOPPADS Drug Info IC50 = 74 nM [526106]
AVVYPWT Drug Info IC50 = 14.3 nM [528976]
LAVYPWT Drug Info IC50 = 32.4 nM [528976]
References
Ref 528976J Med Chem. 2007 Sep 6;50(18):4543-7. Epub 2007 Aug 3.Structure-activity relationship studies of spinorphin as a potent and selective human P2X(3) receptor antagonist.
Ref 526106J Med Chem. 2001 Feb 1;44(3):340-9.Structure-activity relationships of pyridoxal phosphate derivatives as potent and selective antagonists of P2X1 receptors.
Ref 528976J Med Chem. 2007 Sep 6;50(18):4543-7. Epub 2007 Aug 3.Structure-activity relationship studies of spinorphin as a potent and selective human P2X(3) receptor antagonist.
Ref 528976J Med Chem. 2007 Sep 6;50(18):4543-7. Epub 2007 Aug 3.Structure-activity relationship studies of spinorphin as a potent and selective human P2X(3) receptor antagonist.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.