Target Validation Information
Target ID T98896
Target Name Aggrecanase
Target Type
Clinical Trial
Drug Potency against Target SC-44463 Drug Info IC50 = 368 nM [526154]
References
Ref 526154J Med Chem. 2001 Oct 11;44(21):3347-50.Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors.

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