| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T98896 | ||||
| Target Name | Aggrecanase | ||||
| Target Type | Clinical Trial |
||||
| Drug Potency against Target | SC-44463 | Drug Info | IC50 = 368 nM | [526154] | |
| References | |||||
| Ref 526154 | J Med Chem. 2001 Oct 11;44(21):3347-50.Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors. | ||||
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