| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T85605 | ||||
| Target Name | 5-hydroxytryptamine receptor | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | Fenfluramine | Drug Info | IC50 = 11 nM | [553291] | |
| HMR-2934 | Drug Info | IC50 = 11 nM | [552961] | ||
| Bifeprunox | Drug Info | Ki = 1.48 nM | [552493] | ||
| References | |||||
| Ref 553291 | Inhibition by tetanus toxin of sodium-dependent, high-affinity [3H]5-hydroxytryptamine uptake in rat synaptosomes. Biochem Pharmacol. 1999 Jan 1;57(1):111-20. | ||||
| Ref 552961 | End of the line for cannabinoid receptor 1 as an anti-obesity target? An opinion. Nat Rev Drug Discov. 2009 Jul;8(7):594. doi: 10.1038/nrd2775-c1. | ||||
| Ref 552493 | Novel antipsychotics activate recombinant human and native rat serotonin 5-HT1A receptors: affinity, efficacy and potential implications for treatment of schizophrenia. Int J Neuropsychopharmacol. 2005 Sep;8(3):341-56. Epub 2005 Feb 11. | ||||
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