Target Validation Information | |||||
---|---|---|---|---|---|
Target ID | T07217 | ||||
Target Name | Fatty acid-binding protein, adipocyte | ||||
Target Type | Research |
||||
Drug Potency against Target | 3-Carbazol-9-yl-propionic acid | Drug Info | IC50 = 9400 nM | [527208] | |
2-(4-Methyl-indole-1-sulfonyl)-benzoic acid | Drug Info | IC50 = 12000 nM | [527208] | ||
LINOLEIC ACID | Drug Info | IC50 = 1000 nM | [530916] | ||
2-(5-Bromo-indole-1-sulfonyl)-benzoic acid | Drug Info | IC50 = 12000 nM | [527208] | ||
BMS-480404 | Drug Info | Ki = 2.5 nM | [528353] | ||
2-(2,3-bis(2-chlorobenzyloxy)phenyl)acetic acid | Drug Info | Ki = 16 nM | [528353] | ||
2-(3-Methyl-indole-1-sulfonyl)-benzoic acid | Drug Info | IC50 = 8500 nM | [527208] | ||
2-(6-Methoxy-indole-1-sulfonyl)-benzoic acid | Drug Info | IC50 = 6100 nM | [527208] | ||
4-Carbazol-9-yl-butyric acid | Drug Info | IC50 = 570 nM | [527208] | ||
Hexadecanoic acid | Drug Info | IC50 = 930 nM | [527208] | ||
5-Carbazol-9-yl-pentanoic acid | Drug Info | IC50 = 800 nM | [527208] | ||
2-(Carbazole-9-sulfonyl)-benzoic acid | Drug Info | IC50 = 4300 nM | [527208] | ||
2-(4-Fluoro-indole-1-sulfonyl)-benzoic acid | Drug Info | IC50 = 10000 nM | [527208] | ||
1-benzyl-2,3-dimethyl-1H-indole-7-carboxylic acid | Drug Info | IC50 = 3600 nM | [529963] | ||
References | |||||
Ref 527208 | Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8.Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target. | ||||
Ref 527208 | Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8.Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target. | ||||
Ref 530916 | Bioorg Med Chem Lett. 2010 Jun 15;20(12):3675-9. Epub 2010 Apr 24.Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening. | ||||
Ref 527208 | Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8.Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target. | ||||
Ref 528353 | J Med Chem. 2006 Aug 10;49(16):5013-7.NMR structure of a potent small molecule inhibitor bound to human keratinocyte fatty acid-binding protein. | ||||
Ref 528353 | J Med Chem. 2006 Aug 10;49(16):5013-7.NMR structure of a potent small molecule inhibitor bound to human keratinocyte fatty acid-binding protein. | ||||
Ref 527208 | Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8.Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target. | ||||
Ref 527208 | Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8.Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target. | ||||
Ref 527208 | Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8.Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target. | ||||
Ref 527208 | Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8.Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target. | ||||
Ref 527208 | Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8.Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target. | ||||
Ref 527208 | Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8.Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target. | ||||
Ref 527208 | Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8.Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target. | ||||
Ref 529963 | Bioorg Med Chem Lett. 2009 Mar 15;19(6):1745-8. Epub 2009 Jan 30.N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte fatty-acid binding protein (A-FABP) inhibitors. |
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