Target Validation Information
Target ID T19011
Target Name M-phase inducer phosphatase 3
Target Type
Discontinued
Drug Potency against Target BN-82685 Drug Info IC50 = 150 nM [527791]
NSC-663284 Drug Info IC50 = 250 nM [527791]
BN-82002 Drug Info IC50 = 5400 nM [527263]
References
Ref 527791Bioorg Med Chem Lett. 2006 Jan 1;16(1):171-5. Epub 2005 Oct 10.Synthesis and biological evaluation of novel heterocyclic quinones as inhibitors of the dual specificity protein phosphatase CDC25C.
Ref 527791Bioorg Med Chem Lett. 2006 Jan 1;16(1):171-5. Epub 2005 Oct 10.Synthesis and biological evaluation of novel heterocyclic quinones as inhibitors of the dual specificity protein phosphatase CDC25C.
Ref 527263Bioorg Med Chem Lett. 2004 Dec 6;14(23):5809-12.Synthesis of small molecule CDC25 phosphatases inhibitors.

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