| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T95594 | ||||
| Target Name | mRNA of PI3K p110 beta | ||||
| Target Type | Research |
||||
| Drug Potency against Target | 3-(4-morpholinothieno[3,2-d]pyrimidin-2-yl)phenol | Drug Info | IC50 = 16 nM | [528931] | |
| LY-293646 | Drug Info | IC50 = 6000 nM | [526022] | ||
| LY-292223 | Drug Info | IC50 = 14000 nM | [526022] | ||
| References | |||||
| Ref 528931 | Bioorg Med Chem. 2007 Sep 1;15(17):5837-44. Epub 2007 Jun 6.Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110alpha inhibitors. | ||||
| Ref 526022 | Bioorg Med Chem Lett. 2001 Apr 9;11(7):909-13.LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family. | ||||
| Ref 526022 | Bioorg Med Chem Lett. 2001 Apr 9;11(7):909-13.LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family. | ||||
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