Target Validation Information
Target ID T46456
Target Name Retinoic acid receptor RXR-gamma
Target Type
Successful
Drug Potency against Target Bexarotene Drug Info Ki = 21 nM [552986]
AGN-34 Drug Info IC50 < 10 nM [527690]
References
Ref 552986Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene). J Med Chem. 2009 Oct 8;52(19):5950-66. doi: 10.1021/jm900496b.
Ref 527690J Med Chem. 2005 Aug 25;48(17):5383-403.Farnesoid X receptor: from structure to potential clinical applications.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.