| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T13714 | ||||
| Target Name | Oxysterols receptor LXR-beta | ||||
| Target Type | Research |
||||
| Drug Potency against Target | GSK-9772 | Drug Info | IC50 = 30 nM | [529702] | |
| 17-dehydroxyriccardin C | Drug Info | IC50 = 13000 nM | [529375] | ||
| WAY-214950 | Drug Info | IC50 = 33 nM | [529781] | ||
| 4,17-dehydroxyriccardin C | Drug Info | IC50 = 7300 nM | [529375] | ||
| 12,17-dehydroxyriccardin C | Drug Info | IC50 = 14000 nM | [529375] | ||
| Riccardin C | Drug Info | IC50 = 6600 nM | [529375] | ||
| GW-3965 | Drug Info | IC50 = 12 nM | [529781] | ||
| WAY-252623 | Drug Info | IC50 = 24 nM | [529781] | ||
| 2-Benzyl-3-phenyl-7-(trifluoromethyl)-2H-indazole | Drug Info | IC50 = 41 nM | [529781] | ||
| 12-dehydroxyriccardin C | Drug Info | IC50 = 7600 nM | [529375] | ||
| 4-dehydroxyriccardin C | Drug Info | IC50 = 10000 nM | [529375] | ||
| References | |||||
| Ref 529702 | J Med Chem. 2008 Sep 25;51(18):5758-65.Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity. | ||||
| Ref 529375 | Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. Epub 2008 Feb 29.Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. | ||||
| Ref 529781 | J Med Chem. 2008 Nov 27;51(22):7161-8.Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic triglyceride synthesis. | ||||
| Ref 529375 | Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. Epub 2008 Feb 29.Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. | ||||
| Ref 529375 | Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. Epub 2008 Feb 29.Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. | ||||
| Ref 529375 | Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. Epub 2008 Feb 29.Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. | ||||
| Ref 529781 | J Med Chem. 2008 Nov 27;51(22):7161-8.Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic triglyceride synthesis. | ||||
| Ref 529781 | J Med Chem. 2008 Nov 27;51(22):7161-8.Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic triglyceride synthesis. | ||||
| Ref 529781 | J Med Chem. 2008 Nov 27;51(22):7161-8.Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic triglyceride synthesis. | ||||
| Ref 529375 | Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. Epub 2008 Feb 29.Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. | ||||
| Ref 529375 | Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. Epub 2008 Feb 29.Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. | ||||
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