Target Validation Information
Target ID T81735
Target Name DNA-dependent protein kinase catalytic subunit
Target Type
Research
Drug Potency against Target 2-(2-Methyl-morpholin-4-yl)-benzo[h]chromen-4-one Drug Info IC50 = 190 nM [527296]
8-(4-chlorophenyl)-2-morpholin-4-ylchromen-4-one Drug Info IC50 = 2400 nM [527888]
LY-293646 Drug Info IC50 = 230 nM [527888]
2-(4-fluorophenyl)-6-morpholino-4H-pyran-4-one Drug Info IC50 = 350 nM [528738]
2-(3-Fluoro-phenyl)-benzo[h]chromen-4-one Drug Info IC50 = 5710 nM [527386]
2-(2-Fluoro-phenyl)-benzo[h]chromen-4-one Drug Info IC50 = 8590 nM [527386]
2-Pyrrolidin-1-yl-benzo[h]chromen-4-one Drug Info IC50 = 6170 nM [527386]
7-Methoxy-2-morpholin-4-yl-chromen-4-one Drug Info IC50 = 950 nM [527386]
6-Methyl-4-morpholin-4-yl-chromen-2-one Drug Info IC50 = 5350 nM [527386]
4-(6-morpholino-4-oxo-4H-pyran-2-yl)benzonitrile Drug Info IC50 = 2500 nM [528738]
2-(piperidin-1-yl)-4H-benzo[h]chromen-4-one Drug Info IC50 = 3810 nM [527888]
2-(4-methoxyphenyl)-6-morpholino-4H-pyran-4-one Drug Info IC50 = 220 nM [528738]
LY-292223 Drug Info IC50 = 1300 nM [527296]
6-Methoxy-4-morpholin-4-yl-chromen-2-one Drug Info IC50 = 1750 nM [527386]
2-morpholino-6-phenyl-4H-pyran-4-one Drug Info IC50 = 1300 nM [528738]
8-(2-acetylphenyl)-2-morpholin-4-ylchromen-4-one Drug Info IC50 = 14900 nM [527888]
2-morpholin-4-yl-8-thiophen-3-ylchromen-4-one Drug Info IC50 = 300 nM [527888]
8-(4-acetylphenyl)-2-morpholin-4-ylchromen-4-one Drug Info IC50 = 1000 nM [527888]
8-Phenyl-2-thiomorpholin-4-yl-chromen-4-one Drug Info IC50 = 1610 nM [527386]
7-Methoxy-4-morpholin-4-yl-chromen-2-one Drug Info IC50 = 11310 nM [527386]
6-isopropyl-2-morpholin-4-yl-4H-thiopyran-4-one Drug Info IC50 = 5900 nM [528738]
8-Methyl-4-morpholin-4-yl-chromen-2-one Drug Info IC50 = 8050 nM [527386]
6-tert-Butyl-2-morpholin-4-yl-4H-thiopyran-4-one Drug Info IC50 = 1060 nM [528738]
2-morpholin-4-yl-8-phenoxathiin-4-ylchromen-4-one Drug Info IC50 = 5800 nM [527888]
2-(furan-2-yl)-6-morpholino-4H-pyran-4-one Drug Info IC50 = 1000 nM [528738]
2-morpholin-4-yl-8-styrylchromen-4-one Drug Info IC50 = 1500 nM [527888]
8-(3-hydroxyphenyl)-2-morpholin-4-ylchromen-4-one Drug Info IC50 = 1200 nM [527888]
2-Thiomorpholin-4-yl-pyrido[1,2-a]pyrimidin-4-one Drug Info IC50 = 1690 nM [527386]
4-Thiomorpholin-4-yl-benzo[g]chromen-2-one Drug Info IC50 = 5150 nM [527386]
2-Morpholin-4-yl-6-phenyl-chromen-4-one Drug Info IC50 = 2240 nM [527386]
8-Methoxy-4-morpholin-4-yl-chromen-2-one Drug Info IC50 = 10940 nM [527386]
2-Morpholin-4-yl-pyrimido[2,1-a]isoquinolin-4-one Drug Info IC50 = 280 nM [527386]
2-Pyridin-3-yl-benzo[h]chromen-4-one Drug Info IC50 = 1920 nM [527386]
2-Morpholin-4-yl-benzo[h]chromene-4-thione Drug Info IC50 = 260 nM [527386]
ALPHA-NAPHTHOFLAVONE Drug Info IC50 = 4980 nM [527386]
2-[1,4]Oxazepan-4-yl-benzo[h]chromen-4-one Drug Info IC50 = 2010 nM [527386]
1-Morpholin-4-yl-benzo[f]chromen-3-one Drug Info IC50 = 1900 nM [527386]
4-Morpholin-4-yl-chromen-2-one Drug Info IC50 = 4820 nM [527386]
8-Phenyl-2-piperidin-1-yl-chromen-4-one Drug Info IC50 = 4670 nM [527386]
8-dibenzofuran-4-yl-2-morpholin-4-ylchromen-4-one Drug Info IC50 = 40 nM [527888]
2-(4-Amino-phenyl)-benzo[h]chromen-4-one Drug Info IC50 = 7700 nM [527386]
7-phenylethoxy-2-morpholin-4-yl-chromen-4-one Drug Info IC50 = 2990 nM [527888]
8-Methoxy-2-morpholin-4-yl-chromen-4-one Drug Info IC50 = 1200 nM [527386]
6-Chloro-4-morpholin-4-yl-chromen-2-one Drug Info IC50 = 3270 nM [527386]
4-Piperidin-1-yl-chromen-2-one Drug Info IC50 = 8810 nM [527386]
2-morpholin-4-yl-8-naphthalen-2-ylchromen-4-one Drug Info IC50 = 3000 nM [527888]
4-morpholino-6-phenyl-2H-pyran-2-one Drug Info IC50 = 1800 nM [528738]
2-morpholinobenzo[h]quinolin-4(1H)-one Drug Info IC50 = 250 nM [527888]
7-benzoyloxy-2-(morpholin-4-yl)-chromen-4-one Drug Info IC50 = 1680 nM [527888]
8-Methyl-2-morpholin-4-yl-chromen-4-one Drug Info IC50 = 1650 nM [527386]
2-dibenzofuran-4-yl-6-morpholin-4-yl-pyran-4-one Drug Info IC50 = 1200 nM [528738]
2-biphenyl-4-yl-6-morpholin-4-yl-pyran-4-one Drug Info IC50 = 800 nM [528738]
7-propoxy-2-(morpholin-4-yl)-chromen-4-one Drug Info IC50 = 1320 nM [527888]
7-phenyloxyethoxy-2-morpholin-4-yl-chromen-4-one Drug Info IC50 = 4590 nM [527888]
2-(4-chlorophenyl)-6-morpholino-4H-pyran-4-one Drug Info IC50 = 180 nM [528738]
2-morpholino-6-(thiophen-2-yl)-4H-pyran-4-one Drug Info IC50 = 1100 nM [528738]
2-morpholino-6-styryl-4H-pyran-4-one Drug Info IC50 = 4200 nM [528738]
7-benzyloxy-2-(morpholin-4-yl)-chromen-4-one Drug Info IC50 = 380 nM [527888]
2-thiomorpholino-4H-benzo[h]chromen-4-one Drug Info IC50 = 1380 nM [527888]
4-Morpholin-4-yl-benzo[g]chromen-2-one Drug Info IC50 = 3240 nM [527386]
3-(6-morpholino-4-oxo-4H-pyran-2-yl)benzonitrile Drug Info IC50 = 3100 nM [528738]
2-(2-methoxyphenyl)-6-morpholino-4H-pyran-4-one Drug Info IC50 = 310 nM [528738]
KU-55933 Drug Info IC50 = 1800 nM [528738]
2-(3-acetylphenyl)-6-morpholino-4H-pyran-4-one Drug Info IC50 = 4700 nM [528738]
2-morpholino-6-(naphthalen-1-yl)-4H-pyran-4-one Drug Info IC50 = 2300 nM [528738]
3-(6-morpholino-4-oxo-4H-pyran-2-yl)benzaldehyde Drug Info IC50 = 2500 nM [528738]
2-morpholino-6-(thiophen-3-yl)-4H-pyran-4-one Drug Info IC50 = 1600 nM [528738]
2-(3-methoxyphenyl)-6-morpholino-4H-pyran-4-one Drug Info IC50 = 540 nM [528738]
6-(4-chlorophenyl)-2-morpholin-4-ylpyridin-4-ol Drug Info IC50 = 8100 nM [528738]
7-hydroxy-2-(morpholin-4-yl)chromen-4-one Drug Info IC50 = 450 nM [527888]
2-(1H-indol-5-yl)-6-morpholino-4H-pyran-4-one Drug Info IC50 = 400 nM [528738]
6-(4-chlorophenyl)-4-morpholino-2H-pyran-2-one Drug Info IC50 = 470 nM [528738]
3-(6-morpholino-4-oxo-4H-pyran-2-yl)benzoic acid Drug Info IC50 = 7200 nM [528738]
2-morpholino-6-(naphthalen-2-yl)-4H-pyran-4-one Drug Info IC50 = 1300 nM [528738]
8-furan-2-yl-2-morpholin-4-ylchromen-4-one Drug Info IC50 = 2800 nM [527888]
8-(4-hydroxyphenyl)-2-morpholin-4-ylchromen-4-one Drug Info IC50 = 2600 nM [527888]
NU-7432 Drug Info Ki = 0.65 nM [527888]
2-morpholin-4-yl-8-thiophen-2-ylchromen-4-one Drug Info IC50 = 700 nM [527888]
6-(4-methoxyphenyl)-4-morpholino-2H-pyran-2-one Drug Info IC50 = 530 nM [528738]
2-(2-aminophenyl)-6-morpholino-4H-pyran-4-one Drug Info IC50 = 7800 nM [528738]
3-morpholino-1H-benzo[f]chromen-1-one Drug Info IC50 = 1250 nM [528738]
2-morpholin-4-yl-6-phenyl-4H-thiopyran-4-one Drug Info IC50 = 650 nM [528738]
2-morpholino-6-(quinolin-8-yl)-4H-pyran-4-one Drug Info IC50 = 900 nM [528738]
8-biphenyl-2-yl-2-morpholin-4-ylchromen-4-one Drug Info IC50 = 10600 nM [527888]
2-(benzofuran-2-yl)-6-morpholino-4H-pyran-4-one Drug Info IC50 = 800 nM [528738]
7-ethyloxyethoxy-2-morpholin-4-yl-chromen-4-one Drug Info IC50 = 8400 nM [527888]
2-Morpholin-4-yl-pyrido[1,2-a]pyrimidin-4-one Drug Info IC50 = 2000 nM [527386]
2-morpholino-4H-benzo[g]chromen-4-one Drug Info IC50 = 400 nM [527888]
8-(1H-indol-5-yl)-2-morpholin-4-ylchromen-4-one Drug Info IC50 = 2600 nM [527888]
4-Morpholin-4-yl-benzo[h]chromen-2-one Drug Info IC50 = 6660 nM [527386]
References
Ref 527296Bioorg Med Chem Lett. 2004 Dec 20;14(24):6083-7.Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries.
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 527386J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Ref 527386J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Ref 527386J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Ref 527386J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Ref 527386J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 527296Bioorg Med Chem Lett. 2004 Dec 20;14(24):6083-7.Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries.
Ref 527386J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Ref 527386J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Ref 527386J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 527386J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Ref 527386J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Ref 527386J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Ref 527386J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Ref 527386J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Ref 527386J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Ref 527386J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Ref 527386J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Ref 527386J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Ref 527386J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Ref 527386J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Ref 527386J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Ref 527386J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Ref 527386J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Ref 527386J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Ref 527386J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Ref 527386J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Ref 527386J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Ref 527386J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Ref 527386J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Ref 527386J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.

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