| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T10937 | ||||
| Target Name | mRNA of Human mdm2 | ||||
| Target Type | Research |
||||
| Drug Potency against Target | NSC-66811 | Drug Info | Ki = 120 nM | [528263] | |
| PLSQETFSDLWKLLPEN-NH2 | Drug Info | Ki = 6670 nM | [528232] | ||
| NU-8231 | Drug Info | IC50 = 5300 nM | [528471] | ||
| NUTLIN-3 | Drug Info | IC50 = 90 nM | [529211] | ||
| References | |||||
| Ref 528263 | J Med Chem. 2006 Jun 29;49(13):3759-62.Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy. | ||||
| Ref 528232 | J Med Chem. 2006 Jun 15;49(12):3432-5.Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction. | ||||
| Ref 528471 | J Med Chem. 2006 Oct 19;49(21):6209-21.Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold. | ||||
| Ref 529211 | Nature. 2007 Dec 13;450(7172):1001-9.Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. | ||||
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