Target Validation Information | |||||
---|---|---|---|---|---|
Target ID | T21507 | ||||
Target Name | Fatty acid-bindingprotein, epidermal | ||||
Target Type | Research |
||||
Drug Potency against Target | BMS-480404 | Drug Info | Ki = 33 nM | [528353] | |
2-(2,3-bis(2-chlorobenzyloxy)phenyl)acetic acid | Drug Info | Ki = 3 nM | [528353] | ||
5-Carbazol-9-yl-pentanoic acid | Drug Info | IC50 = 3000 nM | [527208] | ||
2-(Carbazole-9-sulfonyl)-benzoic acid | Drug Info | IC50 = 17000 nM | [527208] | ||
4-Carbazol-9-yl-butyric acid | Drug Info | IC50 = 6700 nM | [527208] | ||
Hexadecanoic acid | Drug Info | IC50 = 1200 nM | [527208] | ||
References | |||||
Ref 528353 | J Med Chem. 2006 Aug 10;49(16):5013-7.NMR structure of a potent small molecule inhibitor bound to human keratinocyte fatty acid-binding protein. | ||||
Ref 528353 | J Med Chem. 2006 Aug 10;49(16):5013-7.NMR structure of a potent small molecule inhibitor bound to human keratinocyte fatty acid-binding protein. | ||||
Ref 527208 | Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8.Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target. | ||||
Ref 527208 | Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8.Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target. | ||||
Ref 527208 | Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8.Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target. | ||||
Ref 527208 | Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8.Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target. |
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