| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T61317 | ||||
| Target Name | 3-oxoacyl-[acyl-carrier protein] reductase | ||||
| Target Type | Research |
||||
| Drug Potency against Target | CHRYSIN | Drug Info | IC50 = 10000 nM | [528213] | |
| ISORHAMNETIN | Drug Info | IC50 = 8300 nM | [528213] | ||
| GALLOCATECHIN GALLATE | Drug Info | IC50 = 1100 nM | [528213] | ||
| (-)-CATECHINGALLATE | Drug Info | Ki = 2800 nM | [528213] | ||
| 2-Hexadecynoic acid | Drug Info | Ki = 6000 nM | [531170] | ||
| FISETIN | Drug Info | IC50 = 4100 nM | [528213] | ||
| MORIN | Drug Info | IC50 = 2300 nM | [528213] | ||
| KAEMPFEROL | Drug Info | IC50 = 4000 nM | [528213] | ||
| EPIGALOCATECHIN GALLATE | Drug Info | IC50 = 300 nM | [528213] | ||
| References | |||||
| Ref 528213 | J Med Chem. 2006 Jun 1;49(11):3345-53.Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. | ||||
| Ref 528213 | J Med Chem. 2006 Jun 1;49(11):3345-53.Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. | ||||
| Ref 528213 | J Med Chem. 2006 Jun 1;49(11):3345-53.Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. | ||||
| Ref 528213 | J Med Chem. 2006 Jun 1;49(11):3345-53.Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. | ||||
| Ref 531170 | Bioorg Med Chem. 2010 Nov 1;18(21):7475-85. Epub 2010 Sep 18.2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections. | ||||
| Ref 528213 | J Med Chem. 2006 Jun 1;49(11):3345-53.Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. | ||||
| Ref 528213 | J Med Chem. 2006 Jun 1;49(11):3345-53.Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. | ||||
| Ref 528213 | J Med Chem. 2006 Jun 1;49(11):3345-53.Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. | ||||
| Ref 528213 | J Med Chem. 2006 Jun 1;49(11):3345-53.Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. | ||||
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