| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T91661 | ||||
| Target Name | Adenosine kinase | ||||
| Target Type | Clinical Trial |
||||
| Drug Potency against Target | 6-Benzylthioinosine | Drug Info | Ki = 14300 nM | [530903] | |
| 5-iodo,5'-deoxytubercidin | Drug Info | IC50 = 0.9 nM | [528569] | ||
| References | |||||
| Ref 530903 | Bioorg Med Chem. 2010 May 15;18(10):3403-12. Epub 2010 Apr 8.Structure-activity relationships of carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase. | ||||
| Ref 528569 | J Med Chem. 2006 Nov 16;49(23):6726-31.Crystal structures of human adenosine kinase inhibitor complexes reveal two distinct binding modes. | ||||
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