| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T22769 | ||||
| Target Name | Telomerase protein component 1 | ||||
| Target Type |
Investigate
|
||||
| Drug Potency against Target | Imetelstat | Drug Info | IC50 = 3~300 nM | [552759] | |
| Action against Disease Model | Imetelstat | Extracts from HME50-5E cells lysed with NP-40 lysis buffer were incubated with 0.001-100 nM GRN163 or GRN163L for 30 min and then processed for telomerase activity assays. The IC50 values were approx1.4 and approx7.8 nM for GRN163 and GRN163L, respectively. | Drug Info | ||
| The Effect of Target Knockout, Knockdown or Genetic Variations | Phenotype: male and female infertility; embryonic mortality due to a defective;closure of the neural tube;small size and severe intestinal atrophy;spleen atrophy and reduced proliferation of B and T lymphocytes;impaired germinal centre function;reduced | ||||
| References | |||||
| Ref 552759 | Oligonucleotide conjugate GRN163L targeting human telomerase as potential anticancer and antimetastatic agent. Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1577-9. | ||||
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