Biomarker General Infomation |
Biomarker ID |
BM001323 |
Biomarker Name |
5-HT 2A receptor (HTR2A) |
Disease |
Schizophrenia |
ICD Code |
ICD-11: 6A20
|
Biomarker Type |
Pharmacodynamic; theragnostic |
Molecular Type |
Protein |
Biomarker Location |
striatum; cortex |
Biomarker Measure |
Occupancy |
Specific Aim |
Target occupancy; help dose decision |
Conclusion |
D2 or 5-HT2 receptor occupancy in striatum or cortex as measured using PET or SP ECT, currently considered the most reliable biomarker of target engagements for current antipsychotics. |
Treatment |
antipsychotics |
UniProt ID |
|
References |
REF 1 |
Biomarkers for antipsychotic therapies. Handb Exp Pharmacol. 2012;(212):339-60.
|
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