Biomarker General Infomation
Biomarker ID
BM003100
Biomarker Name
CD28- memory CD8+ T cells
Disease Human immunodeficiency virus infection
ICD Code ICD-11: 1C62 ; ICD-10: B17.1, B18.2
Biomarker Type Differentiation
Biomarker Measure Higher
Conclusion In both HIV infection and aging, immunosenescence is marked by an increased proportion of CD28-, CD57+ memory CD8+ T cells with reduced capacity to produce interleukin 2 (IL-2), increased production of IL-6, resistance to apoptosis, and shortened telomeres.
References
REF 1 Aging, inflammation, and HIV infection. Top Antivir Med. 2012 Aug-Sep;20(3):101-5. Top Antivir Med. 2012 Aug-Sep;20(3):101-5.

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