Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T00884 Target Info
Target Name C-X-C chemokine receptor type 1 (CXCR1)
Synonyms
Interleukin-8 receptor A; IL8RA; IL-8R A; IL-8 receptor type 1; High affinity interleukin-8 receptor A; CXCR-1; CXC-R1; CMKAR1; CDw128a; CD181
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Target Type Successful Target
Gene Name CXCR1
Biochemical Class GPCR rhodopsin
UniProt ID
CXCR1_HUMAN
Co-Targets of This Target  Top
Co-Target Name C-X-C chemokine receptor type 2 (CXCR2) Successful Target
UniProt ID CXCR2_HUMAN
Gene Name CXCR2
Synonyms
Interleukin-8 receptor B; IL8RB; IL-8R B; IL-8 receptor type 2; High affinity interleukin-8 receptor B; GRO/MGSA receptor; CXCR-2; CXC-R2; CDw128b; CD182
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Representative Drug(s) SCH-527123 Drug Info IC50 = 0.049 nM Click to Show More [1]
2 Reparixin Drug Info IC50 = 1 nM [1]
Co-Target Name Prostaglandin G/H synthase 2 (COX-2) Successful Target
UniProt ID PGH2_HUMAN
Gene Name PTGS2
Synonyms
Prostaglandin-endoperoxide synthase 2; Prostaglandin H2 synthase 2; PHS II; PGHS-2; PGH synthase 2; Cyclooxygenase-2; COX2; COX-2
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Representative Drug(s) Ibuprofen Drug Info IC50 = 100 nM [2]
Co-Target Name Prostaglandin G/H synthase 1 (COX-1) Successful Target
UniProt ID PGH1_HUMAN
Gene Name PTGS1
Synonyms
Prostaglandin-endoperoxide synthase 1; Prostaglandin H2 synthase 1; PHS 1; PGHS-1; PGH synthase 1; Cyclooxygenase-1; COX1; COX-1
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Representative Drug(s) Ibuprofen Drug Info IC50 = 290 nM [3]
References  Top
REF 1 Chemokine receptor antagonists. J Med Chem. 2012 Nov 26;55(22):9363-92.
REF 2 Nonsteroidal anti-inflammatory drugs as scaffolds for the design of 5-lipoxygenase inhibitors. J Med Chem. 1997 Feb 28;40(5):819-24.
REF 3 Synthesis, pharmacological characterization, and docking analysis of a novel family of diarylisoxazoles as highly selective cyclooxygenase-1 (COX-1) inhibitors. J Med Chem. 2013 Jun 13;56(11):4277-99.

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