Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T00895 | Target Info | |||
| Target Name | Protein kinase C epsilon (PRKCE) | ||||
| Synonyms |
Protein kinase C epsilon type; PKCE; PKC epsilon; NPKC-epsilon
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| Target Type | Successful Target | ||||
| Gene Name | PRKCE | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Protein kinase C alpha (PRKCA) | Successful Target | ||||
| UniProt ID | KPCA_HUMAN | |||||
| Gene Name | PRKCA | |||||
| Synonyms |
Protein kinase C alpha type; PRKACA; PKCalpha; PKCA; PKC-alpha; PKC-A
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| Representative Drug(s) | Bryostatin-1 | Drug Info | Ki = 0.48 nM | [1] | ||
| Co-Target Name | Protein kinase C delta (PRKCD) | Clinical trial Target | ||||
| UniProt ID | KPCD_HUMAN | |||||
| Gene Name | PRKCD | |||||
| Synonyms |
nPKC-delta; Tyrosine-protein kinase PRKCD; SDK1; Protein kinase C delta type catalytic subunit; Protein kinase C delta type; PKC-delta
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| Representative Drug(s) | Bryostatin-1 | Drug Info | Ki = 0.44 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Neristatin 1 provides critical insight into bryostatin 1 structure-function relationships. J Nat Prod. 2015 Apr 24;78(4):896-900. | ||||
| REF 2 | Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C. J Med Chem. 2009 Jul 9;52(13):3969-81. | ||||
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