Co-Target(s) Information

Content Navigation (  All   None )                                      
Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T02703 Target Info
Target Name Nitric-oxide synthase inducible (NOS2)
Synonyms
iNOS; Peptidyl-cysteine S-nitrosylase NOS2; Nitric oxide synthase, inducible; NOS2A; NOS type II; Inducible NOS; Inducible NO synthase; Hepatocyte NOS; HEP-NOS
    Click to Show/Hide
Target Type Clinical trial Target
Gene Name NOS2
Biochemical Class Paired donor oxygen oxidoreductase
UniProt ID
NOS2_HUMAN
Co-Targets of This Target  Top
Co-Target Name Amyloid beta A4 protein (APP) Successful Target
UniProt ID A4_HUMAN
Gene Name APP
Synonyms
Protease nexin-II; PreA4; PN-II; Cerebral vascular amyloid peptide; CVAP; Amyloid-beta precursor protein; Amyloid-beta A4 protein; Alzheimer disease amyloid protein; APPI; APP; AD1; ABPP; A4
    Click to Show/Hide
Representative Drug(s) Curcumin Drug Info IC50 = 630 nM [1]
Co-Target Name Monoamine oxidase type A (MAO-A) Successful Target
UniProt ID AOFA_HUMAN
Gene Name MAOA
Synonyms
Monoamine oxidase A; Amine oxidase [flavin-containing] A
    Click to Show/Hide
Representative Drug(s) Curcumin Drug Info Ki = 710 nM [2]
Co-Target Name Lactoylglutathione lyase (GLO1) Clinical trial Target
UniProt ID LGUL_HUMAN
Gene Name GLO1
Synonyms
S-D-lactoylglutathione methylglyoxal lyase; Methylglyoxalase; Ketone-aldehyde mutase; Glyoxalase I; GlxI; Glx I; GLO1; Aldoketomutase
    Click to Show/Hide
Representative Drug(s) Curcumin Drug Info Ki = 5 nM [3]
Co-Target Name Tissue factor (F3) Successful Target
UniProt ID TF_HUMAN
Gene Name F3
Synonyms
Thromboplastin; TF; F3; Coagulation factor III; CD142 antigen
    Click to Show/Hide
Representative Drug(s) Curcumin Drug Info IC50 = 13.16 nM [4]
Co-Target Name Prostaglandin E synthase (PTGES) Clinical trial Target
UniProt ID PTGES_HUMAN
Gene Name PTGES
Synonyms
p53-induced gene 12 protein; PIG12; PGES; PGE synthase; P53-induced apoptosis protein 12; Microsomal prostaglandin E synthase 1; Microsomal glutathione S-transferase 1-like 1; MPGES1; MPGES-1; MGST1L1; MGST1-L1
    Click to Show/Hide
Representative Drug(s) Curcumin Drug Info IC50 = 200 nM [5]
Co-Target Name Diamine oxidase (AOC1) Literature-reported Target
UniProt ID AOC1_HUMAN
Gene Name AOC1
Synonyms
Kidney amine oxidase; KAO; Histaminase; Amiloride-binding protein; AOC1; ABP
    Click to Show/Hide
Representative Drug(s) Aminoguanidine Drug Info Ki = 140 nM [6]
Co-Target Name CDGSH iron-sulfur domain-containing protein 1 (CISD1_HUMAN) Co-Target
UniProt ID CISD1_HUMAN
Gene Name CISD1
Synonyms
MitoNEET
    Click to Show/Hide
Representative Drug(s) Curcumin Drug Info Ki = 101 nM [7]
References  Top
REF 1 Neuritogenic activity of bi-functional bis-tryptoline triazole. Bioorg Med Chem. 2017 Feb 1;25(3):1195-1201.
REF 2 Monoamine Oxidase Inhibitory Activity of Novel Pyrazoline Analogues: Curcumin Based Design and Synthesis. ACS Med Chem Lett. 2015 Dec 1;7(1):56-61.
REF 3 Recent advances in the discovery and development of glyoxalase I inhibitors. Bioorg Med Chem. 2020 Feb 15;28(4):115243.
REF 4 Microbial hydroxylation and glycosylation of pentacyclic triterpenes as inhibitors on tissue factor procoagulant activity. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1026-30.
REF 5 Targeting microsomal prostaglandin E2 synthase-1 (mPGES-1): the development of inhibitors as an alternative to non-steroidal anti-inflammatory drugs (NSAIDs). Medchemcomm. 2015;6:2081-123.
REF 6 Synthesis of 4(5)-imidazolyl allylamines and propargylamines as inhibitors of diamine oxidase. Bioorg Med Chem Lett. 1993 Feb;3(2):353-6.
REF 7 Identification of small molecules that bind to the mitochondrial protein mitoNEET. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5350-5353.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.