Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T02719 | Target Info | |||
| Target Name | Metabotropic glutamate receptor 3 (mGluR3) | ||||
| Synonyms |
mGLUR3; Group III metabotropic glutamate receptor; GPRC1C
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| Target Type | Clinical trial Target | ||||
| Gene Name | GRM3 | ||||
| Biochemical Class | GPCR glutamate | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Metabotropic glutamate receptor 2 (mGluR2) | Clinical trial Target | ||||
| UniProt ID | GRM2_HUMAN | |||||
| Gene Name | GRM2 | |||||
| Synonyms |
mGLUR2; Group II metabotropic glutamate receptor; Glutamate receptor mGLU2; GPRC1B
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| Representative Drug(s) | BCI-632 | Drug Info | Ki = 2.2 nM | Click to Show More | [1] | |
| 2 | LY404039 | Drug Info | EC50 = 23.4 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Radiosynthesis of PET radiotracer as a prodrug for imaging group II metabotropic glutamate receptors in vivo. Bioorg Med Chem Lett. 2012 Mar 1;22(5):1958-62. | ||||
| REF 2 | Synthesis and metabotropic glutamate receptor activity of S-oxidized variants of (-)-4-amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate: identif... J Med Chem. 2007 Jan 25;50(2):233-40. | ||||
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