Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T02728 | Target Info | |||
| Target Name | Neurotensin receptor type 1 (NTSR1) | ||||
| Synonyms |
NTSR1; NTRH; NTR1; NTR subtype 1; NT-R1; NT-R-1; High-affinity levocabastine-insensitive neurotensin receptor
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| Target Type | Clinical trial Target | ||||
| Gene Name | NTSR1 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Neurotensin receptor type 2 (NTSR2) | Literature-reported Target | ||||
| UniProt ID | NTR2_HUMAN | |||||
| Gene Name | NTSR2 | |||||
| Synonyms |
NTR2; NT-R-2; Levocabastine-sensitive neurotensin receptor
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| Representative Drug(s) | Meclinertant | Drug Info | Ki = 418 nM | [1] | ||
| Co-Target Name | Sortilin (SORT1) | Co-Target | ||||
| UniProt ID | SORT_HUMAN | |||||
| Gene Name | SORT1 | |||||
| Synonyms |
100 kDa NT receptor; Glycoprotein 95; Gp95; Neurotensin receptor 3; NT3; NTR3
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| Representative Drug(s) | Meclinertant | Drug Info | IC50 = 238 nM | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The synthesis of neurotensin antagonist SR 48692 for prostate cancer research. Bioorg Med Chem. 2013 Jul 15;21(14):4378-87. | ||||
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