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| Target General Information |
Top |
| Target ID |
T02728 |
Target Info
|
| Target Name |
Neurotensin receptor type 1 (NTSR1) |
| Synonyms |
NTSR1; NTRH; NTR1; NTR subtype 1; NT-R1; NT-R-1; High-affinity levocabastine-insensitive neurotensin receptor |
| Target Type |
Clinical trial Target |
| Gene Name |
NTSR1 |
| Biochemical Class |
GPCR rhodopsin |
| UniProt ID |
|
| Co-Targets of This Target |
Top |
| Co-Target Name |
Neurotensin receptor type 2 (NTSR2) |
Literature-reported Target |
| UniProt ID |
NTR2_HUMAN
|
| Gene Name |
NTSR2
|
| Synonyms |
NTR2; NT-R-2; Levocabastine-sensitive neurotensin receptor |
| Representative Drug(s) |
Meclinertant |
Drug Info
|
Ki = 418 nM |
[1] |
| Co-Target Name |
Sortilin (SORT1) |
Co-Target |
| UniProt ID |
SORT_HUMAN
|
| Gene Name |
SORT1
|
| Synonyms |
100 kDa NT receptor; Glycoprotein 95; Gp95; Neurotensin receptor 3; NT3; NTR3 |
| Representative Drug(s) |
Meclinertant |
Drug Info
|
IC50 = 238 nM |
[1] |
| References |
Top |
| REF 1 |
The synthesis of neurotensin antagonist SR 48692 for prostate cancer research. Bioorg Med Chem. 2013 Jul 15;21(14):4378-87.
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