Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T03917 | Target Info | |||
| Target Name | Sodium/potassium-transporting ATPase (SPT ATPase) | ||||
| Synonyms |
Na(+)/K(+) ATPase
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| Target Type | Successful Target | ||||
| Gene Name | ATP1A1; ATP1A2; ATP1A3; ATP1B1; ATP1B2; ATP1B3 | ||||
| Biochemical Class | Acid anhydrides hydrolase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Organic anion transporter M1 (SLCO4C1) | Successful Target | ||||
| UniProt ID | SO4C1_HUMAN | |||||
| Gene Name | SLCO4C1 | |||||
| Synonyms |
Solute carrier organic anion transporter family member 4C1; Solute carrier family 21 member 20; OATPX; OATP4C1; OATP-M1; OATP-H
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| Representative Drug(s) | Digitoxin | Drug Info | IC50 = 120 nM | [1] | ||
| Co-Target Name | Signal transducer and activator of transcription 3 (STAT3) | Successful Target | ||||
| UniProt ID | STAT3_HUMAN | |||||
| Gene Name | STAT3 | |||||
| Synonyms |
Acute-phase response factor; APRF
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| Representative Drug(s) | Digitoxin | Drug Info | IC50 = 700 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3569-74. | ||||
| REF 2 | PubChem BioAssay: 2017 update. Nucleic Acids Res. 2017 Jan 4;45(D1):D955-D963. | ||||
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