Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T05409 Target Info
Target Name Neutral endopeptidase (MME)
Synonyms
Skin fibroblast elastase; SFE; Neutral endopeptidase 24.11; Neprilysin; NEP protein; Enkephalinase; EPN; Common acute lymphocytic leukemia antigen; CD10; CALLA; Atriopeptidase
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Target Type Clinical trial Target
Gene Name MME
Biochemical Class Peptidase
UniProt ID
NEP_HUMAN
Co-Targets of This Target  Top
Co-Target Name Voltage-gated L-type calcium channel (L-CaC) Successful Target
UniProt ID CAC1C_HUMAN; CAC1D_HUMAN; CAC1F_HUMAN; CAC1S_HUMAN
Gene Name NO-GeName
Synonyms
L-type voltage-dependent Ca(2+) channel; L-type Ca2+ channel; L-type Ca(2+) channel
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Representative Drug(s) Gallopamil Drug Info Ki = 5.4 nM [1]
Co-Target Name Angiotensin-converting enzyme (ACE) Successful Target
UniProt ID ACE_HUMAN
Gene Name SLC33A1
Synonyms
Kininase II; Dipeptidyl carboxypeptidase I; DCP1; DCP; CD143 antigen; CD143; ACE
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Representative Drug(s) Sampatrilat Drug Info Ki = 13.8 nM [2]
Co-Target Name Voltage-gated calcium channel alpha Cav1.2 (CACNA1C) Successful Target
UniProt ID CAC1C_HUMAN
Gene Name CACNA1C
Synonyms
Voltage-gated calcium channel subunit alpha Cav1.2; Voltage-dependent L-type calcium channel subunit alpha-1C; Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; CCHL1A1; CACNL1A1; CACN2; CACH2
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Representative Drug(s) Gallopamil Drug Info IC50 = 17 nM [3]
Co-Target Name Natriuretic peptides A (NPPA) Co-Target
UniProt ID ANF_HUMAN
Gene Name NPPA
Synonyms
Atrial natriuretic factor prohormone; proANF; Atrial natriuretic peptide prohormone; preproANP; proANP; Atriopeptigen; Cardiodilatin; CDD; preproCDD-ANF
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Representative Drug(s) Sampatrilat Drug Info IC50 = 3.4 nM [4]
References  Top
REF 1 Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds. Eur J Med Chem. 2013 May;63:85-94.
REF 2 Molecular Basis for Omapatrilat and Sampatrilat Binding to Neprilysin-Implications for Dual Inhibitor Design with Angiotensin-Converting Enzyme. J Med Chem. 2020 May 28;63(10):5488-5500.
REF 3 Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment. J Appl Toxicol. 2012 Oct;32(10):858-66.
REF 4 Synthesis and evaluation of heteroarylalanine diacids as potent and selective neutral endopeptidase inhibitors. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3404-6.

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