Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T07279 | Target Info | |||
| Target Name | Serine/threonine-protein kinase pim-2 (PIM2) | ||||
| Synonyms |
Pim-2h; PIM2
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| Target Type | Clinical trial Target | ||||
| Gene Name | PIM2 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Serine/threonine-protein kinase pim-1 (PIM1) | Clinical trial Target | ||||
| UniProt ID | PIM1_HUMAN | |||||
| Gene Name | PIM1 | |||||
| Synonyms |
Pim-1 proto-oncogene, serine/threonine kinase; PIM
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| Representative Drug(s) | LGH-447 | Drug Info | IC50 = 0.006 nM | Click to Show More | [1] | |
| 2 | AZD1208 | Drug Info | Ki = 0.017 nM | [2] | ||
| Co-Target Name | PIM-3 protein kinase (PIM3) | Patented-recorded Target | ||||
| UniProt ID | PIM3_HUMAN | |||||
| Gene Name | PIM3 | |||||
| Synonyms |
Serine/threonine-protein kinase pim-3
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| Representative Drug(s) | LGH-447 | Drug Info | IC50 = 0.009 nM | Click to Show More | [1] | |
| 2 | AZD1208 | Drug Info | Ki = 0.23 nM | [3] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Targeting the immunity protein kinases for immuno-oncology. Eur J Med Chem. 2019 Feb 1;163:413-427. | ||||
| REF 2 | Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors. ACS Med Chem Lett. 2013 Oct 15;4(12):1193-7. | ||||
| REF 3 | Identification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies. J Med Chem. 2015 Nov 12;58(21):8373-86. | ||||
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