Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T08856 Target Info
Target Name Matrix metalloproteinase-8 (MMP-8)
Synonyms PMNL-CL; PMNL collagenase; Neutrophil collagenase; CLG1
Target Type Clinical trial Target
Gene Name MMP8
Biochemical Class Peptidase
UniProt ID
MMP8_HUMAN
Co-Targets of This Target  Top
Co-Target Name Matrix metalloproteinase-1 (MMP-1) Successful Target
UniProt ID MMP1_HUMAN
Gene Name MMP1
Synonyms Interstitial collagenase; Fibroblast collagenase; CLG
Representative Drug(s) CIPEMASTAT Drug Info Ki = 0.3 nM [1]
Co-Target Name Matrix metalloproteinase-7 (MMP-7) Successful Target
UniProt ID MMP7_HUMAN
Gene Name MMP7
Synonyms Uterine metalloproteinase; Pump-1 protease; PUMP1; Matrin; Matrilysin; MPSL1
Representative Drug(s) CIPEMASTAT Drug Info IC50 = 18.5 nM [2]
Co-Target Name Matrix metalloproteinase-2 (MMP-2) Successful Target
UniProt ID MMP2_HUMAN
Gene Name MMP2
Synonyms TBE-1; Matrix metalloproteinase 2; CLG4A; 72 kDa type IV collagenase; 72 kDa gelatinase
Representative Drug(s) CIPEMASTAT Drug Info IC50 = 154 nM [3]
Co-Target Name Matrix metalloproteinase-13 (MMP-13) Clinical trial Target
UniProt ID MMP13_HUMAN
Gene Name MMP13
Synonyms Matrix metalloproteinase 13; Collagenase-3; Collagenase 3
Representative Drug(s) CIPEMASTAT Drug Info Ki = 0.53 nM [2]
Co-Target Name Matrix metalloproteinase-9 (MMP-9) Clinical trial Target
UniProt ID MMP9_HUMAN
Gene Name MMP9
Synonyms Matrix metalloproteinase 9; GELB; CLG4B; 92 kDa type IV collagenase; 92 kDa gelatinase
Representative Drug(s) CIPEMASTAT Drug Info IC50 = 2.4 nM [2]
Co-Target Name Matrix metalloproteinase-14 (MMP-14) Clinical trial Target
UniProt ID MMP14_HUMAN
Gene Name MMP14
Synonyms Membrane-type-1 matrix metalloproteinase; Membrane-type matrix metalloproteinase 1; MTMMP1; MT1MMP; MT1-MMP; MT-MMP 1; MMP-X1
Representative Drug(s) CIPEMASTAT Drug Info IC50 = 23 nM [2]
Co-Target Name TNF alpha converting enzyme (ADAM17) Clinical trial Target
UniProt ID ADA17_HUMAN
Gene Name ADAM17
Synonyms TNFalpha converting enzyme; TNF-alpha-converting enzyme; TNF-alpha converting enzyme; TNF-alpha convertase; TACE; Snake venom-like protease; Disintegrin and metalloproteinase domain-containing protein 17; CSVP; CD156b antigen; CD156b; ADAM 17; A disintegrin and metalloproteinase domain 17
Representative Drug(s) CIPEMASTAT Drug Info Ki = 230 nM [1]
Co-Target Name Matrix metalloproteinase-3 (MMP-3) Patented-recorded Target
UniProt ID MMP3_HUMAN
Gene Name MMP3
Synonyms Transin-1; Stromelysin-1; STMY1; SL-1; MMP-3
Representative Drug(s) CIPEMASTAT Drug Info Ki = 56 nM [1]
References  Top
REF 1 A cassette-dosing approach for improvement of oral bioavailability of dual TACE/MMP inhibitors. Bioorg Med Chem Lett. 2006 May 15;16(10):2632-6.
REF 2 Discovery of potent, selective, and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13. J Med Chem. 2009 Jun 11;52(11):3523-38.
REF 3 Stereospecific synthesis of 5-substituted 2-bisarylthiocyclopentane carboxylic acids as specific matrix metalloproteinase inhibitors. J Med Chem. 2003 Aug 28;46(18):3840-52.

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