Co-Target(s) Information

Content Navigation (  All   None )                                      
Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T08910 Target Info
Target Name GABA(A) receptor gamma-2 (GABRG2)
Synonyms
Gamma-aminobutyric acid receptor subunit gamma-2; GABA(A) receptor subunit gamma-2
    Click to Show/Hide
Target Type Successful Target
Gene Name GABRG2
Biochemical Class Neurotransmitter receptor
UniProt ID
GBRG2_HUMAN
Co-Targets of This Target  Top
Co-Target Name Gamma-aminobutyric acid B receptor (GABBR) Successful Target
UniProt ID GABR1_HUMAN; GABR2_HUMAN
Gene Name GABBR1; GABBR2
Synonyms
Gamma-aminobutyric acid type B receptor; GPRC3; GABABR; GABA-BR; GABA-B-R; GABA-B receptor
    Click to Show/Hide
Representative Drug(s) GSK683699 Drug Info IC50 = 25 nM [1]
Co-Target Name GABA transporter-3 (SLC6A11) Clinical trial Target
UniProt ID S6A11_HUMAN
Gene Name SLC6A11
Synonyms
Solute carrier family 6 member 11; Sodium- and chloride-dependent GABA transporter 3; GAT3; GAT-3; GABT3
    Click to Show/Hide
Representative Drug(s) GSK683699 Drug Info IC50 = 1000 nM [2]
Co-Target Name GABA(A) receptor rho1 (GABRR1) Literature-reported Target
UniProt ID GBRR1_HUMAN
Gene Name GABRR1
Synonyms
Gamma-aminobutyric acid receptor subunit rho-1; GABA(C) receptor1; GABA(A) receptor subunit rho-1
    Click to Show/Hide
Representative Drug(s) GSK683699 Drug Info EC50 = 269.15 nM [3]
Co-Target Name Na(+)/Cl(-) betaine/GABA transporter (SLC6A12) Literature-reported Target
UniProt ID S6A12_HUMAN
Gene Name SLC6A12
Synonyms
Solute carrier family 6 member 12; Sodium- and chloride-dependent betaine transporter; BGT-1
    Click to Show/Hide
Representative Drug(s) GSK683699 Drug Info IC50 = 851.14 nM [2]
Co-Target Name GABA-A receptor alpha-4/beta-3/delta (GABRA4/GABRB3/GABRD) Co-Target
UniProt ID GBRA4_HUMAN-GBRB3_HUMAN-GBRD_HUMAN
Gene Name GABRA4-GABRB3-GABRD
Representative Drug(s) Allopregnanolone Drug Info EC50 = 75.5 nM [4]
References  Top
REF 1 Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists. J Med Chem. 1995 Aug 18;38(17):3297-312.
REF 2 Structure-Activity Relationship, Pharmacological Characterization, and Molecular Modeling of Noncompetitive Inhibitors of the Betaine/-Aminobutyric Acid Transporter 1 (BGT1). J Med Chem. 2017 Nov 9;60(21):8834-8846.
REF 3 Synthesis and biological evaluation of 4-(aminomethyl)-1-hydroxypyrazole analogues of muscimol as -aminobutyric acid(a) receptor agonists. J Med Chem. 2013 Feb 14;56(3):993-1006.
REF 4 Neuroactive Steroids. 2. 3alpha-Hydroxy-3beta-methyl-21-(4-cyano-1H-pyrazol-1'-yl)-19-nor-5beta-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (gamma-Aminobutyric Acid)?A?Receptor. J Med Chem. 2017 Sep 28;60(18):7810-7819.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.