Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T09960 | Target Info | |||
| Target Name | C-C chemokine receptor type 5 (CCR5) | ||||
| Synonyms |
HIV-1 fusion coreceptor; HIV-1 fusion co-receptor; Chemokine receptor CCR5; CMKBR5; CHEMR13; CD195 antigen; CD195; CCR-5; CC-CKR-5; C-C CKR-5
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| Target Type | Successful Target | ||||
| Gene Name | CCR5 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | C-X-C chemokine receptor type 5 (CXCR5) | Clinical trial Target | ||||
| UniProt ID | CXCR5_HUMAN | |||||
| Gene Name | CXCR5 | |||||
| Synonyms |
Monocyte-derived receptor15; Monocyte-derived receptor 15; MDR15; MDR-15; Chemokine receptor CXCR5; CXCR-5; CXC-R5; CD185; Burkitt'S lymphoma receptor 1; Burkitt lymphoma receptor 1; BLR1
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| Representative Drug(s) | Maraviroc | Drug Info | IC50 = 0.0024 ug.mL-1 | [1] | ||
| Co-Target Name | C-C chemokine receptor type 2 (CCR2) | Clinical trial Target | ||||
| UniProt ID | CCR2_HUMAN | |||||
| Gene Name | CCR2 | |||||
| Synonyms |
Monocyte chemoattractant protein 1 receptor; MCP-1-R; Chemokine receptor CCR2B; CMKBR2; CD192; CCR-2; CC-CKR-2; C-C CKR-2
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| Representative Drug(s) | Cenicriviroc | Drug Info | IC50 = 5.9 nM | [2] | ||
| Co-Target Name | C-C chemokine receptor type 7 (CCR7) | Literature-reported Target | ||||
| UniProt ID | CCR7_HUMAN | |||||
| Gene Name | CCR7 | |||||
| Synonyms |
MIP3 beta receptor; MIP-3 beta receptor; EpsteinBarr virusinduced Gprotein coupled receptor 1; Epstein-Barr virus-induced G-protein coupled receptor 1; EVI1; EBVinduced Gprotein coupled receptor 1; EBV-induced G-protein coupled receptor 1; EBI1; CMKBR7; CDw197; CD197; CCR-7; CCCKR7; CC-CKR-7; CC chemokine receptor type 7; CC CKR7; C-C CKR-7; BLR2
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| Representative Drug(s) | Cenicriviroc | Drug Info | IC50 = 3.1 nM | [3] | ||
| References | Top | ||||
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| REF 1 | HIV-1 X4 activities of polycationic "viologen" based dendrimers by interaction with the chemokine receptor CXCR4: study of structure-activity relationship. J Med Chem. 2012 Dec 13;55(23):10405-13. | ||||
| REF 2 | Chemokine receptor antagonists. J Med Chem. 2012 Nov 26;55(22):9363-92. | ||||
| REF 3 | The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease. J Med Chem. 2020 May 28;63(10):5031-5073. | ||||
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