Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T11843 Target Info
Target Name Vitamin K epoxide reductase complex 1 (VKORC1)
Synonyms
Vitamin K1 2,3-epoxide reductase subunit 1; VKORC1; VKOR; UNQ308/PRO351; MSTP576; MSTP134
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Target Type Successful Target
Gene Name VKORC1
Biochemical Class Short-chain dehydrogenases reductase
UniProt ID
VKOR1_HUMAN
Co-Targets of This Target  Top
Co-Target Name Human immunodeficiency virus Protease (HIV PR) Successful Target
UniProt ID POL_HV1B1
Gene Name HIV PR
Synonyms
HIV Retropepsin; HIV PR
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Representative Drug(s) Phenprocoumon Drug Info Ki = 0.8 nM [1]
Co-Target Name S-mephenytoin 4-hydroxylase (CYP2C9) Successful Target
UniProt ID CP2C9_HUMAN
Gene Name CYP2C9
Synonyms
Cytochrome P450 PB-1; Cytochrome P450 MP-8; Cytochrome P450 MP-4; Cytochrome P450 2C9; Cytochrome P-450MP; Cholesterol 25-hydroxylase; CYPIIC9; CYP2C10; (S)-limonene 7-monooxygenase; (S)-limonene 6-monooxygenase; (R)-limonene 6-monooxygenase
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Representative Drug(s) Dicumarol Drug Info Ki = 600 nM [2]
Co-Target Name Quinone reductase 1 (NQO1) Clinical trial Target
UniProt ID NQO1_HUMAN
Gene Name NQO1
Synonyms
Qui reductase 1; QR1; Phylloquinone reductase; Phylloqui reductase; NMOR1; NAD(P)H:quinone oxidoreductase 1; NAD(P)H dehydrogenase [quinone] 1; Menadione reductase; DTD; DT-diaphorase 1; DT-diaphorase; DIA4; Azoreductase
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Representative Drug(s) Dicumarol Drug Info IC50 = 2.6 nM [3]
Co-Target Name Kynurenic acid receptor (GPR35) Literature-reported Target
UniProt ID GPR35_HUMAN
Gene Name GPR35
Synonyms
KYNA receptor; Gprotein coupled receptor 35; GPR35
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Representative Drug(s) Dicumarol Drug Info Ki = 39 nM [4]
References  Top
REF 1 Structure-based design of nonpeptidic HIV protease inhibitors: the sulfonamide-substituted cyclooctylpyramones. J Med Chem. 1997 Mar 28;40(7):1149-64.
REF 2 A refined 3-dimensional QSAR of cytochrome P450 2C9: computational predictions of drug interactions. J Med Chem. 2000 Jul 27;43(15):2789-96.
REF 3 Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1). J Med Chem. 2009 Nov 26;52(22):7142-56.
REF 4 6-Bromo-8-(4-[(3)H]methoxybenzamido)-4-oxo-4H-chromene-2-carboxylic Acid: a powerful tool for studying orphan G protein-coupled receptor GPR35. J Med Chem. 2013 Sep 12;56(17):7084-99.

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