Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T15497 Target Info
Target Name Prostaglandin E2 receptor EP1 (PTGER1)
Synonyms
Prostanoid EP1 receptor; Prostaglandin E2 receptor EP1 subtype; PGE2 receptor EP1 subtype; PGE receptor, EP1 subtype; PGE receptor EP1 subtype; EP1 receptor
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Target Type Clinical trial Target
Gene Name PTGER1
Biochemical Class GPCR rhodopsin
UniProt ID
PE2R1_HUMAN
Co-Targets of This Target  Top
Co-Target Name Thromboxane A2 receptor (TBXA2R) Successful Target
UniProt ID TA2R_HUMAN
Gene Name TBXA2R
Synonyms
TXA2-R; TXA2 receptor; Prostanoid TP receptor
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Representative Drug(s) PGF2alpha Drug Info IC50 ~ 0.001 nM [1]
Co-Target Name Prostaglandin F2-alpha receptor (PTGFR) Successful Target
UniProt ID PF2R_HUMAN
Gene Name PTGFR
Synonyms
Prostanoid FP receptor; PGF2-alpha receptor; PGF2 alpha receptor; PGF receptor; FP prostanoid receptor; FP prostaglandin receptor
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Representative Drug(s) PGF2alpha Drug Info IC50 = 2.5 nM [2]
Co-Target Name Prostaglandin E2 receptor EP3 (PTGER3) Clinical trial Target
UniProt ID PE2R3_HUMAN
Gene Name PTGER3
Synonyms
Prostanoid EP3 receptor; Prostaglandin E2 receptor EP3 subtype; PGE2-R; PGE2 receptor EP3 subtype; PGE receptor, EP3 subtype; PGE receptor EP3 subtype
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Representative Drug(s) PGF2alpha Drug Info IC50 = 110 nM [1]
Co-Target Name Prostaglandin transporter (SLC21A2) Patented-recorded Target
UniProt ID SO2A1_HUMAN
Gene Name SLCO2A1
Synonyms
Solute carrier organic anion transporter family member 2A1; Solute carrier family 21 member 2; PGT; OATP2A1
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Representative Drug(s) PGF2alpha Drug Info Ki = 23 nM [3]
References  Top
REF 1 Synthesis and biological evaluation of prostaglandin-F alkylphosphinic acid derivatives as bone anabolic agents for the treatment of osteoporosis. J Med Chem. 2001 Nov 22;44(24):4157-69.
REF 2 Synthesis and in vitro evaluation of human FP-receptor selective prostaglandin analogues. Bioorg Med Chem Lett. 2000 Jul 17;10(14):1519-22.
REF 3 Cloning of mouse prostaglandin transporter PGT cDNA: species-specific substrate affinities. Am J Physiol. 1999 Sep;277(3):R734-41.

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