Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T20089 Target Info
Target Name Plasmodium Deoxyribonucleic acid (Malaria DNA)
Target Type Successful Target
Gene Name NO-GeName
UniProt ID
NOUNIPROTAC
Co-Targets of This Target  Top
Co-Target Name Serotonin transporter (SERT) Successful Target
UniProt ID SC6A4_HUMAN
Gene Name SLC6A4
Synonyms
Solute carrier family 6 member 4; HTT; 5HTT; 5HT transporter
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Representative Drug(s) Primaquine Drug Info Ki = 8.405 nM [1]
Co-Target Name Cytochrome P450 1A2 (CYP1A2) Co-Target
UniProt ID CP1A2_HUMAN
Gene Name CYP1A2
Synonyms
Cholesterol 25-hydroxylase; Hydroperoxy icosatetraenoate dehydratase; CYPIA2; Cytochrome P(3)450; Cytochrome P450 4; Cytochrome P450-P3
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Representative Drug(s) Primaquine Drug Info IC50 = 182.4 nM [1]
Co-Target Name Glycine hydroxymethyltransferase (SHMT2) Co-Target
UniProt ID GLYM_HUMAN
Gene Name SHMT2
Synonyms
Serine hydroxymethyltransferase, mitochondrial; SHMT; Serine methylase
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Representative Drug(s) Primaquine Drug Info IC50 = 436.52 nM [2]
References  Top
REF 1 DrugMatrix in vitro pharmacology data. National Toxicology Program
REF 2 WHO patent application no. 2016085990A1, COMPOSITIONS AND METHODS RELATING TO INHIBITING SERINE HYRDOXYMETHYLTRANSFERASE 2 ACTIVITY.

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