Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T20761 Target Info
Target Name Vascular endothelial growth factor A (VEGFA)
Synonyms
Vascular permeability factor; VPF; VEGF-A; VEGF
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Target Type Successful Target
Gene Name VEGFA
Biochemical Class Growth factor
UniProt ID
VEGFA_HUMAN
Co-Targets of This Target  Top
Co-Target Name Farnesoid X-activated receptor (FXR) Successful Target
UniProt ID NR1H4_HUMAN
Gene Name NR1H4
Synonyms
Retinoid X receptor-interacting protein 14; RXR-interacting protein 14; RIP14; Nuclear receptor subfamily 1 group H member 4; HRR1; Farnesol receptor HRR-1; FXR; Bile acid receptor; BAR
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Representative Drug(s) Bevacizumab + Trastuzumab Drug Info IC50 = 18.3 nM [1]
Co-Target Name Indoleamine 2,3-dioxygenase 1 (IDO1) Successful Target
UniProt ID I23O1_HUMAN
Gene Name IDO1
Synonyms
Indoleamine-pyrrole 2,3-dioxygenase; INDO; IDO-1; IDO
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Representative Drug(s) Avastin+/-Tarceva Drug Info IC50 = 1000 nM [2]
Co-Target Name G-protein coupled bile acid receptor 1 (GPBAR1) Clinical trial Target
UniProt ID GPBAR_HUMAN
Gene Name GPBAR1
Synonyms
hGPCR19; hBG37; TGR5; Membrane-type receptor for bile acids; M-BAR; G-protein coupled receptor GPCR19; BG37
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Representative Drug(s) Bevacizumab + Trastuzumab Drug Info EC50 = 580 nM [3]
References  Top
REF 1 Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor. Bioorg Med Chem. 2014 Jun 1;22(11):2919-38.
REF 2 Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. J Med Chem. 2008 Mar 27;51(6):1706-18.
REF 3 Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. J Med Chem. 2008 Mar 27;51(6):1831-41.

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