Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T22655 Target Info
Target Name Mucosal addressin cell adhesion molecule 1 (MADCAM1)
Synonyms
hMAdCAM-1; MAdCAM-1; MADCAM1
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Target Type Clinical trial Target
Gene Name MADCAM1
UniProt ID
MADCA_HUMAN
Co-Targets of This Target  Top
Co-Target Name C-X-C chemokine receptor type 2 (CXCR2) Successful Target
UniProt ID CXCR2_HUMAN
Gene Name CXCR2
Synonyms
Interleukin-8 receptor B; IL8RB; IL-8R B; IL-8 receptor type 2; High affinity interleukin-8 receptor B; GRO/MGSA receptor; CXCR-2; CXC-R2; CDw128b; CD182
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Representative Drug(s) SCH-527123 Drug Info IC50 = 0.049 nM [1]
Co-Target Name C-X-C chemokine receptor type 1 (CXCR1) Successful Target
UniProt ID CXCR1_HUMAN
Gene Name CXCR1
Synonyms
Interleukin-8 receptor A; IL8RA; IL-8R A; IL-8 receptor type 1; High affinity interleukin-8 receptor A; CXCR-1; CXC-R1; CMKAR1; CDw128a; CD181
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Representative Drug(s) SCH-527123 Drug Info IC50 = 3.9 nM [1]
Co-Target Name Interleukin 8 receptor (IL8R) Literature-reported Target
UniProt ID CXCR1_HUMAN; CXCR2_HUMAN
Gene Name CXCR1; CXCR2
Synonyms
IL8R; IL-8R; IL-8 receptor; High affinity interleukin-8 receptor; CXCR; CXC-R; CDw128
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Representative Drug(s) SCH-527123 Drug Info IC50 = 16 nM [2]
References  Top
REF 1 Chemokine receptor antagonists. J Med Chem. 2012 Nov 26;55(22):9363-92.
REF 2 Discovery of 2-hydroxy-N,N-dimethyl-3-{2-[[(R)-1-(5- methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123): a potent, orally bioavailable CXCR2/CXCR1 receptor antagonist. J Med Chem. 2006 Dec 28;49(26):7603-6.

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