Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T25265 | Target Info | |||
| Target Name | Enhancer of zeste homolog 2 (EZH2) | ||||
| Synonyms |
Lysine Nmethyltransferase 6; Lysine N-methyltransferase 6; KMT6; Histonelysine Nmethyltransferase EZH2; Histone-lysine N-methyltransferase EZH2; EZH2; ENX1; ENX-1
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| Target Type | Successful Target | ||||
| Gene Name | EZH2 | ||||
| Biochemical Class | Methyltransferase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Embryonic ectoderm development protein (EED) | Clinical trial Target | ||||
| UniProt ID | EED_HUMAN | |||||
| Gene Name | EED | |||||
| Synonyms |
hEED; WD protein associating with integrin cytoplasmic tails 1; WAIT-1
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| Representative Drug(s) | Tazemetostat | Drug Info | IC50 = 2 nM | [1] | ||
| Co-Target Name | EZH1/SUZ12/EED/AEBP2/RBBP4 complex | Co-Target | ||||
| UniProt ID | EZH1_HUMAN-SUZ12_HUMAN-EED_HUMAN-AEBP2_HUMAN-RBBP4_HUMAN | |||||
| Gene Name | EZH1-SUZ12-EED-AEBP2-RBBP4 | |||||
| Representative Drug(s) | Tazemetostat | Drug Info | IC50 = 4 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy. J Med Chem. 2017 Mar 23;60(6):2215-2226. | ||||
| REF 2 | Discovery of EBI-2511: A Highly Potent and Orally Active EZH2 Inhibitor for the Treatment of Non-Hodgkin's Lymphoma. ACS Med Chem Lett. 2018 Jan 29;9(2):98-102. | ||||
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