Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T26500 | Target Info | |||
| Target Name | Histamine H4 receptor (H4R) | ||||
| Synonyms |
SP9144; Pfi-013; HH4R; H4 receptor; GPRv53; GPCR105; G protein-coupled receptor 105; AXOR35
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| Target Type | Clinical trial Target | ||||
| Gene Name | HRH4 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Histamine H3 receptor (H3R) | Clinical trial Target | ||||
| UniProt ID | HRH3_HUMAN | |||||
| Gene Name | HRH3 | |||||
| Synonyms |
Histamine receptor 3; HH3R; GPCR97; G-protein coupled receptor 97; G protein-coupled receptor 97
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| Representative Drug(s) | PF-3893787 | Drug Info | Ki = 186.21 nM | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: comparison of hERG binding and target residence time with PF-3893787. Bioorg Med Chem Lett. 2013 May 1;23(9):2663-70. | ||||
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