Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T29999 Target Info
Target Name Vasopressin V1 receptor (V1R)
Synonyms
Vasopressin receptor 1; ADH V1 receptor
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Target Type Successful Target
Gene Name NO-GeName
UniProt ID
NOUNIPROTAC
Co-Targets of This Target  Top
Co-Target Name Vasopressin V2 receptor (V2R) Successful Target
UniProt ID V2R_HUMAN
Gene Name AVPR2
Synonyms
Renal-type arginine vasopressin receptor; DIR3; DIR; Antidiuretic hormone receptor; AVPR V2; ADHR
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Representative Drug(s) Mozavaptan Drug Info Ki = 9.42 nM [1]
Co-Target Name Aldehyde oxidase (AOX1) Successful Target
UniProt ID AOXA_HUMAN
Gene Name AOX1
Synonyms
AOX1
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Representative Drug(s) Menadione Drug Info IC50 = 200 nM [2]
Co-Target Name Indoleamine 2,3-dioxygenase 1 (IDO1) Successful Target
UniProt ID I23O1_HUMAN
Gene Name IDO1
Synonyms
Indoleamine-pyrrole 2,3-dioxygenase; INDO; IDO-1; IDO
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Representative Drug(s) Menadione Drug Info IC50 = 370 nM [3]
Co-Target Name Monoamine oxidase type B (MAO-B) Successful Target
UniProt ID AOFB_HUMAN
Gene Name MAOB
Synonyms
MAO-B; Amine oxidase [flavin-containing] B
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Representative Drug(s) Menadione Drug Info Ki = 400 nM [4]
Co-Target Name Oxytocin receptor (OTR) Successful Target
UniProt ID OXYR_HUMAN
Gene Name OXTR
Synonyms
OT-R
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Representative Drug(s) Mozavaptan Drug Info Ki = 660 nM [5]
Co-Target Name Thiosulfate sulfurtransferase (TST) Co-Target
UniProt ID THTR_HUMAN
Gene Name TST
Synonyms
Rhodanese
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Representative Drug(s) Menadione Drug Info IC50 = 1000 nM [6]
References  Top
REF 1 Novel design of nonpeptide AVP V(2) receptor agonists: structural requirements for an agonist having 1-(4-aminobenzoyl)-2,3,4, 5-tetrahydro-1H-1-benzazepine as a template. J Med Chem. 2000 Nov 16;43(23):4388-97.
REF 2 Aldehyde oxidase: an enzyme of emerging importance in drug discovery. J Med Chem. 2010 Dec 23;53(24):8441-60.
REF 3 Polyketides and Anthranilic Acid Possessing 6-Deoxy-alpha-l-talopyranose from a Streptomyces Species. J Nat Prod. 2017 May 26;80(5):1378-86.
REF 4 Molecular insights into human monoamine oxidase (MAO) inhibition by 1,4-naphthoquinone: evidences for menadione (vitamin K3) acting as a competitive and reversible inhibitor of MAO. Bioorg Med Chem. 2011 Dec 15;19(24):7416-24.
REF 5 Selective fluorescent nonpeptidic antagonists for vasopressin V? GPCR: application to ligand screening and oligomerization assays. J Med Chem. 2012 Oct 25;55(20):8588-602.
REF 6 HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules. Bioorg Med Chem Lett. 2019 May 1;29(9):1106-1112.

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